The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion
Gastric cancer (GC) is recognized as one of the most common deadly malignancies worldwide and about 40–50% of patients present at diagnosis with an unresectable disease due to a locally advanced or already metastatic condition. Recently, therapeutic options for management of metastatic GC (mGC) have...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1002435/full |
| _version_ | 1811177680587980800 |
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| author | Stefano Cascinu Maria Di Bartolomeo Sara Lonardi Giordano Beretta Lorenzo Fornaro Ferdinando De Vita |
| author_facet | Stefano Cascinu Maria Di Bartolomeo Sara Lonardi Giordano Beretta Lorenzo Fornaro Ferdinando De Vita |
| author_sort | Stefano Cascinu |
| collection | DOAJ |
| description | Gastric cancer (GC) is recognized as one of the most common deadly malignancies worldwide and about 40–50% of patients present at diagnosis with an unresectable disease due to a locally advanced or already metastatic condition. Recently, therapeutic options for management of metastatic GC (mGC) have been approved allowing a potential improvement of patient cancer treatment response and also an establishment of a continuum of care for this aggressive disease. This report is the result of a literature review by an expert panel. The aim of this document is to provide evidence, wherever it is lacking, to provide expert opinion directed at strategic management of mGC, and in particular aspect at practical management where appropriate guidelines are not available. Treatment landscape with new therapeutic strategies for third line and beyond, role of imaging, prognostic factors, symptoms, and markers as well as the importance of multidisciplinary approach particularly the nutritional aspects are discussed. |
| first_indexed | 2024-04-11T06:06:24Z |
| format | Article |
| id | doaj.art-631a15ab8ef749eb86d8e9524296b32f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T06:06:24Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-631a15ab8ef749eb86d8e9524296b32f2022-12-22T04:41:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10024351002435The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinionStefano Cascinu0Maria Di Bartolomeo1Sara Lonardi2Giordano Beretta3Lorenzo Fornaro4Ferdinando De Vita5Comprehensive Cancer Center, IRCCS Ospedale San Raffaele, Università Vita-Salute San Raffaele, Milan, ItalyDepartment of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyMedical Oncology Unit 3, Veneto Institute of Oncology IOV - IRCCS, Padua, ItalyUOC Oncologia Medica, ASL Pescara P.O., Pescara, ItalyUnit of Medical Oncology, Azienda Ospedaliero Universitaria Pisana, Pisa, ItalyOncologia Medica - Dipartimento di Medicina di Precisione, Università degli Studi della Campania Luigi Vanvitelli, Naples, ItalyGastric cancer (GC) is recognized as one of the most common deadly malignancies worldwide and about 40–50% of patients present at diagnosis with an unresectable disease due to a locally advanced or already metastatic condition. Recently, therapeutic options for management of metastatic GC (mGC) have been approved allowing a potential improvement of patient cancer treatment response and also an establishment of a continuum of care for this aggressive disease. This report is the result of a literature review by an expert panel. The aim of this document is to provide evidence, wherever it is lacking, to provide expert opinion directed at strategic management of mGC, and in particular aspect at practical management where appropriate guidelines are not available. Treatment landscape with new therapeutic strategies for third line and beyond, role of imaging, prognostic factors, symptoms, and markers as well as the importance of multidisciplinary approach particularly the nutritional aspects are discussed.https://www.frontiersin.org/articles/10.3389/fmed.2022.1002435/fullmetastatic gastric cancerimmune checkpoint inhibitorstrifluridine/tipiracilmanagementmalnutritiontumor markers |
| spellingShingle | Stefano Cascinu Maria Di Bartolomeo Sara Lonardi Giordano Beretta Lorenzo Fornaro Ferdinando De Vita The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion Frontiers in Medicine metastatic gastric cancer immune checkpoint inhibitors trifluridine/tipiracil management malnutrition tumor markers |
| title | The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion |
| title_full | The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion |
| title_fullStr | The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion |
| title_full_unstemmed | The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion |
| title_short | The evolving strategies for the management of patients with metastatic gastric cancer: A narrative review and expert opinion |
| title_sort | evolving strategies for the management of patients with metastatic gastric cancer a narrative review and expert opinion |
| topic | metastatic gastric cancer immune checkpoint inhibitors trifluridine/tipiracil management malnutrition tumor markers |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1002435/full |
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