The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants
Background: The values of the skin prick test (SPT) and allergen-specific IgE (sIgE) measurement in predicting dog and cat allergies remain unclear. We aimed to evaluate the usefulness of SPT and sIgE measurement in predicting self-reported allergic symptoms during exposure to dogs and cats in Korea...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455120303914 |
| _version_ | 1818917353410265088 |
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| author | Sung-Yoon Kang Min-Suk Yang So-Young Park Jung-Hyun Kim Ha-Kyeong Won Oh Young Kwon Ji-Hyang Lee Ye-Won Kang Jae-Woo Jung Woo-Jung Song Sae-Hoon Kim Sang Min Lee Sang Pyo Lee |
| author_facet | Sung-Yoon Kang Min-Suk Yang So-Young Park Jung-Hyun Kim Ha-Kyeong Won Oh Young Kwon Ji-Hyang Lee Ye-Won Kang Jae-Woo Jung Woo-Jung Song Sae-Hoon Kim Sang Min Lee Sang Pyo Lee |
| author_sort | Sung-Yoon Kang |
| collection | DOAJ |
| description | Background: The values of the skin prick test (SPT) and allergen-specific IgE (sIgE) measurement in predicting dog and cat allergies remain unclear. We aimed to evaluate the usefulness of SPT and sIgE measurement in predicting self-reported allergic symptoms during exposure to dogs and cats in Korean adults. Methods: A total of 552 participants in a pet exhibition in Korea completed questionnaires regarding exposure to dog or cat and the development of allergic symptoms during exposure. Study participants also underwent SPT using 3 different commercially available reagents, and had their blood drawn for measurement of serum total IgE and dog/cat-dander-IgE using ImmunoCAP®. Results: Measurement of sIgE for dog and cat dander allergens provided the highest positive and negative predictive values and sensitivity, but not specificity (58%, 87.2%, 67.9%, and 93.1% for allergic symptoms on dog exposure; 64.7%, 83.2%, 74.8%, and 88.9% for those on cat exposure, respectively), in predicting self-reported allergic symptoms on dog and cat exposure. The sIgE level consistently exhibited the highest area under the receiver operating characteristic curve (0.749 and 0.719 for allergic symptoms on dog and cat exposure, respectively). Careful interpretation of SPT and sIgE measurements maximized the positive and negative predictive values, sensitivity, and specificity for predicting allergic symptoms on dog exposure (71.4%, 87.3%, 75.3%, and 99.3%) and those on cat exposure (71.4%, 85.3%, 79.3%, and 98.9%). Conclusions: The measurement of dog and cat dander sIgE levels may be useful for the exclusion of allergic symptoms related to pet exposure. Collective interpretation of SPT and sIgE tests facilitates identification of allergic symptoms on dog or cat exposure, giving a better rule-in test result. |
| first_indexed | 2024-12-20T00:32:43Z |
| format | Article |
| id | doaj.art-631ab7fb3f4f4b3992d5f621c2aaf098 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-20T00:32:43Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-631ab7fb3f4f4b3992d5f621c2aaf0982022-12-21T19:59:52ZengElsevierWorld Allergy Organization Journal1939-45512020-12-011312100488The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participantsSung-Yoon Kang0Min-Suk Yang1So-Young Park2Jung-Hyun Kim3Ha-Kyeong Won4Oh Young Kwon5Ji-Hyang Lee6Ye-Won Kang7Jae-Woo Jung8Woo-Jung Song9Sae-Hoon Kim10Sang Min Lee11Sang Pyo Lee12Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of KoreaDepartment of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of KoreaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of KoreaDepartment of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Republic of KoreaDepartment of Internal Medicine, Veterans Health Service Medical Center, Seoul, Republic of KoreaDreamKwon Internal Medicine Allergy Clinic, Seoul, Republic of KoreaDepartment of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of KoreaDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of KoreaDepartment of Allergy and Clinical Immunology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Corresponding author. Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam, 13620, Republic of Korea.Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea; Corresponding author. Department of Internal Medicine, Gachon University Gil Medical Center, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea.Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of KoreaBackground: The values of the skin prick test (SPT) and allergen-specific IgE (sIgE) measurement in predicting dog and cat allergies remain unclear. We aimed to evaluate the usefulness of SPT and sIgE measurement in predicting self-reported allergic symptoms during exposure to dogs and cats in Korean adults. Methods: A total of 552 participants in a pet exhibition in Korea completed questionnaires regarding exposure to dog or cat and the development of allergic symptoms during exposure. Study participants also underwent SPT using 3 different commercially available reagents, and had their blood drawn for measurement of serum total IgE and dog/cat-dander-IgE using ImmunoCAP®. Results: Measurement of sIgE for dog and cat dander allergens provided the highest positive and negative predictive values and sensitivity, but not specificity (58%, 87.2%, 67.9%, and 93.1% for allergic symptoms on dog exposure; 64.7%, 83.2%, 74.8%, and 88.9% for those on cat exposure, respectively), in predicting self-reported allergic symptoms on dog and cat exposure. The sIgE level consistently exhibited the highest area under the receiver operating characteristic curve (0.749 and 0.719 for allergic symptoms on dog and cat exposure, respectively). Careful interpretation of SPT and sIgE measurements maximized the positive and negative predictive values, sensitivity, and specificity for predicting allergic symptoms on dog exposure (71.4%, 87.3%, 75.3%, and 99.3%) and those on cat exposure (71.4%, 85.3%, 79.3%, and 98.9%). Conclusions: The measurement of dog and cat dander sIgE levels may be useful for the exclusion of allergic symptoms related to pet exposure. Collective interpretation of SPT and sIgE tests facilitates identification of allergic symptoms on dog or cat exposure, giving a better rule-in test result.http://www.sciencedirect.com/science/article/pii/S1939455120303914AllergyCatsDogsSkin prick testSpecific IgE |
| spellingShingle | Sung-Yoon Kang Min-Suk Yang So-Young Park Jung-Hyun Kim Ha-Kyeong Won Oh Young Kwon Ji-Hyang Lee Ye-Won Kang Jae-Woo Jung Woo-Jung Song Sae-Hoon Kim Sang Min Lee Sang Pyo Lee The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants World Allergy Organization Journal Allergy Cats Dogs Skin prick test Specific IgE |
| title | The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants |
| title_full | The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants |
| title_fullStr | The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants |
| title_full_unstemmed | The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants |
| title_short | The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants |
| title_sort | role of allergen specific ige in predicting allergic symptoms on dog and cat exposure among korean pet exhibition participants |
| topic | Allergy Cats Dogs Skin prick test Specific IgE |
| url | http://www.sciencedirect.com/science/article/pii/S1939455120303914 |
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