Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer

Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer

Abstract Background It is generally accepted that colorectal cancer (CRC) originates from cancer stem cells (CSCs), which are responsible for CRC progression, metastasis and therapy resistance. The high heterogeneity of CSCs has precluded clinical application of CSC-targeting therapy. Here, we aimed...

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Bibliographic Details
Main Authors: Hang Zheng, Heshu Liu, Huayu Li, Weidong Dou, Jingui Wang, Junling Zhang, Tao Liu, Yingchao Wu, Yucun Liu, Xin Wang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Stem Cell Research & Therapy
Subjects:
Colorectal cancer
Stemness
Bioinformatics
Tumor microenvironment
Immunotherapy
Online Access:https://doi.org/10.1186/s13287-022-02913-0

Internet

https://doi.org/10.1186/s13287-022-02913-0

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