The use of chitosan as a skin-regeneration agent in burns injuries: A review
Chitosan is an amino-polysaccharide, traditionally obtained by the partial deacetylation of chitin from exoskeletons of crustaceans. Properties such as biocompatibility, hemostasis, and the ability to absorb physiological fluids are attributed to this biopolymer. Chitosan’s biological properties are...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-01-01
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| Series: | e-Polymers |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/epoly-2022-0011 |
| _version_ | 1811203714282684416 |
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| author | Sánchez-Machado Dalia I. López-Cervantes Jaime Martínez-Ibarra Diana M. Escárcega-Galaz Ana A. Vega-Cázarez Claudia A. |
| author_facet | Sánchez-Machado Dalia I. López-Cervantes Jaime Martínez-Ibarra Diana M. Escárcega-Galaz Ana A. Vega-Cázarez Claudia A. |
| author_sort | Sánchez-Machado Dalia I. |
| collection | DOAJ |
| description | Chitosan is an amino-polysaccharide, traditionally obtained by the partial deacetylation of chitin from exoskeletons of crustaceans. Properties such as biocompatibility, hemostasis, and the ability to absorb physiological fluids are attributed to this biopolymer. Chitosan’s biological properties are regulated by its origin, polymerization degree, and molecular weight. In addition, it possesses antibacterial and antifungal activities. It also has been used to prepare films, hydrogels, coatings, nanofibers, and absorbent sponges, all utilized for the healing of skin wounds. In in vivo studies with second-degree burns, healing has been achieved in at least 80% of the cases between the ninth and twelfth day of treatment with chitosan coatings. The crucial steps in the treatment of severe burns are the early excision of damaged tissue and adequate coverage to minimize the risk of infection. So far, partial-thickness autografting is considered the gold standard for the treatment of full-thickness burns. However, the limitations of donor sites have led to the development of skin substitutes. Therefore, the need for an appropriate dermal equivalent that functions as a regeneration template for the growth and deposition of new skin tissue has been recognized. This review describes the properties of chitosan that validate its potential in the treatment of skin burns. |
| first_indexed | 2024-04-12T02:59:30Z |
| format | Article |
| id | doaj.art-631d12f27d24485ab5d9c71a4d6cad65 |
| institution | Directory Open Access Journal |
| issn | 1618-7229 |
| language | English |
| last_indexed | 2024-04-12T02:59:30Z |
| publishDate | 2022-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | e-Polymers |
| spelling | doaj.art-631d12f27d24485ab5d9c71a4d6cad652022-12-22T03:50:42ZengDe Gruytere-Polymers1618-72292022-01-01221758610.1515/epoly-2022-0011The use of chitosan as a skin-regeneration agent in burns injuries: A reviewSánchez-Machado Dalia I.0López-Cervantes Jaime1Martínez-Ibarra Diana M.2Escárcega-Galaz Ana A.3Vega-Cázarez Claudia A.4Departamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora, MX 85000 Ciudad Obregón, Sonora, MexicoDepartamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora, MX 85000 Ciudad Obregón, Sonora, MexicoDepartamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora, MX 85000 Ciudad Obregón, Sonora, MexicoDepartamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora, MX 85000 Ciudad Obregón, Sonora, MexicoDepartamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora, MX 85000 Ciudad Obregón, Sonora, MexicoChitosan is an amino-polysaccharide, traditionally obtained by the partial deacetylation of chitin from exoskeletons of crustaceans. Properties such as biocompatibility, hemostasis, and the ability to absorb physiological fluids are attributed to this biopolymer. Chitosan’s biological properties are regulated by its origin, polymerization degree, and molecular weight. In addition, it possesses antibacterial and antifungal activities. It also has been used to prepare films, hydrogels, coatings, nanofibers, and absorbent sponges, all utilized for the healing of skin wounds. In in vivo studies with second-degree burns, healing has been achieved in at least 80% of the cases between the ninth and twelfth day of treatment with chitosan coatings. The crucial steps in the treatment of severe burns are the early excision of damaged tissue and adequate coverage to minimize the risk of infection. So far, partial-thickness autografting is considered the gold standard for the treatment of full-thickness burns. However, the limitations of donor sites have led to the development of skin substitutes. Therefore, the need for an appropriate dermal equivalent that functions as a regeneration template for the growth and deposition of new skin tissue has been recognized. This review describes the properties of chitosan that validate its potential in the treatment of skin burns.https://doi.org/10.1515/epoly-2022-0011burnschitosanbiomaterialwound healingtopical treatment |
| spellingShingle | Sánchez-Machado Dalia I. López-Cervantes Jaime Martínez-Ibarra Diana M. Escárcega-Galaz Ana A. Vega-Cázarez Claudia A. The use of chitosan as a skin-regeneration agent in burns injuries: A review e-Polymers burns chitosan biomaterial wound healing topical treatment |
| title | The use of chitosan as a skin-regeneration agent in burns injuries: A review |
| title_full | The use of chitosan as a skin-regeneration agent in burns injuries: A review |
| title_fullStr | The use of chitosan as a skin-regeneration agent in burns injuries: A review |
| title_full_unstemmed | The use of chitosan as a skin-regeneration agent in burns injuries: A review |
| title_short | The use of chitosan as a skin-regeneration agent in burns injuries: A review |
| title_sort | use of chitosan as a skin regeneration agent in burns injuries a review |
| topic | burns chitosan biomaterial wound healing topical treatment |
| url | https://doi.org/10.1515/epoly-2022-0011 |
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