AIF1: Function and Connection with Inflammatory Diseases
Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling an...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/5/694 |
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| author | Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Luis García-Puente Antonio Rios-Parra Maria J. Garrido-Gil Carlos Casanova-Martín Natalio García-Honduvilla Julia Bujan Luis G. Guijarro Melchor Alvarez-Mon Miguel A. Ortega |
| author_facet | Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Luis García-Puente Antonio Rios-Parra Maria J. Garrido-Gil Carlos Casanova-Martín Natalio García-Honduvilla Julia Bujan Luis G. Guijarro Melchor Alvarez-Mon Miguel A. Ortega |
| author_sort | Diego De Leon-Oliva |
| collection | DOAJ |
| description | Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases. |
| first_indexed | 2024-03-11T03:55:42Z |
| format | Article |
| id | doaj.art-631df3890cb94fa9b2132738ff5879fd |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T03:55:42Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-631df3890cb94fa9b2132738ff5879fd2023-11-18T00:33:05ZengMDPI AGBiology2079-77372023-05-0112569410.3390/biology12050694AIF1: Function and Connection with Inflammatory DiseasesDiego De Leon-Oliva0Cielo Garcia-Montero1Oscar Fraile-Martinez2Diego Liviu Boaru3Luis García-Puente4Antonio Rios-Parra5Maria J. Garrido-Gil6Carlos Casanova-Martín7Natalio García-Honduvilla8Julia Bujan9Luis G. Guijarro10Melchor Alvarez-Mon11Miguel A. Ortega12Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainMacrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.https://www.mdpi.com/2079-7737/12/5/694allograft inflammatory factor 1macrophagesmicrogliaphagocytosisintracellular signaling |
| spellingShingle | Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Luis García-Puente Antonio Rios-Parra Maria J. Garrido-Gil Carlos Casanova-Martín Natalio García-Honduvilla Julia Bujan Luis G. Guijarro Melchor Alvarez-Mon Miguel A. Ortega AIF1: Function and Connection with Inflammatory Diseases Biology allograft inflammatory factor 1 macrophages microglia phagocytosis intracellular signaling |
| title | AIF1: Function and Connection with Inflammatory Diseases |
| title_full | AIF1: Function and Connection with Inflammatory Diseases |
| title_fullStr | AIF1: Function and Connection with Inflammatory Diseases |
| title_full_unstemmed | AIF1: Function and Connection with Inflammatory Diseases |
| title_short | AIF1: Function and Connection with Inflammatory Diseases |
| title_sort | aif1 function and connection with inflammatory diseases |
| topic | allograft inflammatory factor 1 macrophages microglia phagocytosis intracellular signaling |
| url | https://www.mdpi.com/2079-7737/12/5/694 |
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