Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers
Hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) including continuous diffuse oxygen therapy (CDOT) are often utilized to enhance wound healing in patients with diabetic foot ulcerations. High pressure pure oxygen assists in the oxygenation of hypoxic wounds to increase perfusion. A...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/7/925 |
| _version_ | 1797529219704553472 |
|---|---|
| author | Alisha R. Oropallo Thomas E. Serena David G. Armstrong Mark Q. Niederauer |
| author_facet | Alisha R. Oropallo Thomas E. Serena David G. Armstrong Mark Q. Niederauer |
| author_sort | Alisha R. Oropallo |
| collection | DOAJ |
| description | Hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) including continuous diffuse oxygen therapy (CDOT) are often utilized to enhance wound healing in patients with diabetic foot ulcerations. High pressure pure oxygen assists in the oxygenation of hypoxic wounds to increase perfusion. Although oxygen therapy provides wound healing benefits to some patients with diabetic foot ulcers, it is currently performed from clinical examination and imaging. Data suggest that oxygen therapy promotes wound healing via angiogenesis, the creation of new blood vessels. Molecular biomarkers relating to tissue inflammation, repair, and healing have been identified. Predictive biomarkers can be used to identify patients who will most likely benefit from this specialized treatment. In diabetic foot ulcerations, specifically, certain biomarkers have been linked to factors involving angiogenesis and inflammation, two crucial aspects of wound healing. In this review, the mechanism of how oxygen works in wound healing on a physiological basis, such as cell metabolism and growth factor signaling transduction is detailed. Additionally, observable clinical outcomes such as collagen formation, angiogenesis, respiratory burst and cell proliferation are described. The scientific evidence for the impact of oxygen on biomolecular pathways and its relationship to the outcomes in clinical research is discussed in this narrative review. |
| first_indexed | 2024-03-10T10:10:39Z |
| format | Article |
| id | doaj.art-631df784735842909cd81e6b3e8895cb |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T10:10:39Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-631df784735842909cd81e6b3e8895cb2023-11-22T01:11:58ZengMDPI AGBiomolecules2218-273X2021-06-0111792510.3390/biom11070925Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot UlcersAlisha R. Oropallo0Thomas E. Serena1David G. Armstrong2Mark Q. Niederauer3Comprehensive Wound Healing Center and Hyperbarics, Department of Vascular Surgery, Zucker School of Medicine Hofstra/Northwell, Hempstead, NY 11549, USASerena Group Research Foundation, Cambridge, MA 02140, USALimb Preservation Program, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USAEO2 Concepts, San Antonio, TX 78249, USAHyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) including continuous diffuse oxygen therapy (CDOT) are often utilized to enhance wound healing in patients with diabetic foot ulcerations. High pressure pure oxygen assists in the oxygenation of hypoxic wounds to increase perfusion. Although oxygen therapy provides wound healing benefits to some patients with diabetic foot ulcers, it is currently performed from clinical examination and imaging. Data suggest that oxygen therapy promotes wound healing via angiogenesis, the creation of new blood vessels. Molecular biomarkers relating to tissue inflammation, repair, and healing have been identified. Predictive biomarkers can be used to identify patients who will most likely benefit from this specialized treatment. In diabetic foot ulcerations, specifically, certain biomarkers have been linked to factors involving angiogenesis and inflammation, two crucial aspects of wound healing. In this review, the mechanism of how oxygen works in wound healing on a physiological basis, such as cell metabolism and growth factor signaling transduction is detailed. Additionally, observable clinical outcomes such as collagen formation, angiogenesis, respiratory burst and cell proliferation are described. The scientific evidence for the impact of oxygen on biomolecular pathways and its relationship to the outcomes in clinical research is discussed in this narrative review.https://www.mdpi.com/2218-273X/11/7/925oxygenhyperbarictopical oxygencontinuous diffusion oxygendiabetic foot ulcermolecular biomarkers |
| spellingShingle | Alisha R. Oropallo Thomas E. Serena David G. Armstrong Mark Q. Niederauer Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers Biomolecules oxygen hyperbaric topical oxygen continuous diffusion oxygen diabetic foot ulcer molecular biomarkers |
| title | Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers |
| title_full | Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers |
| title_fullStr | Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers |
| title_full_unstemmed | Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers |
| title_short | Molecular Biomarkers of Oxygen Therapy in Patients with Diabetic Foot Ulcers |
| title_sort | molecular biomarkers of oxygen therapy in patients with diabetic foot ulcers |
| topic | oxygen hyperbaric topical oxygen continuous diffusion oxygen diabetic foot ulcer molecular biomarkers |
| url | https://www.mdpi.com/2218-273X/11/7/925 |
| work_keys_str_mv | AT alisharoropallo molecularbiomarkersofoxygentherapyinpatientswithdiabeticfootulcers AT thomaseserena molecularbiomarkersofoxygentherapyinpatientswithdiabeticfootulcers AT davidgarmstrong molecularbiomarkersofoxygentherapyinpatientswithdiabeticfootulcers AT markqniederauer molecularbiomarkersofoxygentherapyinpatientswithdiabeticfootulcers |