Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone gene, clarinet (cla-1). cla-1 mutants exhibit defects in synaptic vesicle clustering, active zone structure and syn...

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Bibliographic Details
Main Authors: Zhao Xuan, Laura Manning, Jessica Nelson, Janet E Richmond, Daniel A Colón-Ramos, Kang Shen, Peri T Kurshan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
synapse
active zone
presynaptic plasticity
synaptic vesicle
synaptogenesis
Online Access:https://elifesciences.org/articles/29276

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