Properdin and Factor H: Opposing players on the alternative complement pathway see-saw

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw

Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by promoting proteolytic degradation of C3b. While fact...

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Bibliographic Details
Main Authors: Lubna eKouser, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Uday eKishore
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Immunology
Subjects:
Properdin
biosynthesis
complement
factor H
extrahepatic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00093/full

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