piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02844-1 |
| Summary: | Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued apoptosis and anti-proliferative effects in parental HT1080 cells, as well as DNA damage by regulating RRM2 and CYP1A2. |
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| ISSN: | 2399-3642 |