Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development

Summary: During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study human neural development and disease. Especially in the field of Alzheimer’s disease (AD), remarkable effort has been put into investigating molecular mechanisms behind this disease. Then, wit...

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Bibliographic Details
Main Authors: Tereza Vanova, Jiri Sedmik, Jan Raska, Katerina Amruz Cerna, Petr Taus, Veronika Pospisilova, Marketa Nezvedova, Veronika Fedorova, Sona Kadakova, Hana Klimova, Michaela Capandova, Petra Orviska, Petr Fojtik, Simona Bartova, Karla Plevova, Zdenek Spacil, Hana Hribkova, Dasa Bohaciakova
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013220

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