Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides.
Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C7- or C8-modified purines have mostly been prepared using palladium cross-coupling reactions and then studied as antitumoral and antiviral...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00010/full |
| _version_ | 1818294247628996608 |
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| author | CHRISTOPHE eLEN Gwénaelle eHervé |
| author_facet | CHRISTOPHE eLEN Gwénaelle eHervé |
| author_sort | CHRISTOPHE eLEN |
| collection | DOAJ |
| description | Nucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C7- or C8-modified purines have mostly been prepared using palladium cross-coupling reactions and then studied as antitumoral and antiviral agents. Our objective is to focus this review on the Suzuki-Miyaura and on the Heck cross-couplings of nucleosides using microwave irradiations which are an alternative technology compatible with green chemistry and sustainable development. |
| first_indexed | 2024-12-13T03:28:43Z |
| format | Article |
| id | doaj.art-63204540e5f242c69ef38e4db1fb0883 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-13T03:28:43Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-63204540e5f242c69ef38e4db1fb08832022-12-22T00:01:12ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462015-02-01310.3389/fchem.2015.00010130213Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides.CHRISTOPHE eLEN0Gwénaelle eHervé1Université de Technologie de CompiègneESCOMNucleoside analogues have attracted much attention due to their potential biological activities. Amongst all synthetic nucleosides, C5-modified pyrimidines and C7- or C8-modified purines have mostly been prepared using palladium cross-coupling reactions and then studied as antitumoral and antiviral agents. Our objective is to focus this review on the Suzuki-Miyaura and on the Heck cross-couplings of nucleosides using microwave irradiations which are an alternative technology compatible with green chemistry and sustainable development.http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00010/fullWatergreen chemistryMicrowavenucleotideNucleosideSuzuki-Miyaura |
| spellingShingle | CHRISTOPHE eLEN Gwénaelle eHervé Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. Frontiers in Chemistry Water green chemistry Microwave nucleotide Nucleoside Suzuki-Miyaura |
| title | Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. |
| title_full | Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. |
| title_fullStr | Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. |
| title_full_unstemmed | Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. |
| title_short | Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. |
| title_sort | aqueous microwaves assisted cross coupling reactions applied to unprotected nucleosides |
| topic | Water green chemistry Microwave nucleotide Nucleoside Suzuki-Miyaura |
| url | http://journal.frontiersin.org/Journal/10.3389/fchem.2015.00010/full |
| work_keys_str_mv | AT christopheelen aqueousmicrowavesassistedcrosscouplingreactionsappliedtounprotectednucleosides AT gwenaelleeherve aqueousmicrowavesassistedcrosscouplingreactionsappliedtounprotectednucleosides |