Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia
Is this paper we present a summary of our association analyses of schizophrenia polygenic risk score with a number of phenotypes in a large cohort of people from the UK population (N=442,192). We show that individuals with higher genetic loading to schizophrenia who have not been diagnosed with neur...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/291 |
| _version_ | 1797694660999643136 |
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| author | V. Escott-Price |
| author_facet | V. Escott-Price |
| author_sort | V. Escott-Price |
| collection | DOAJ |
| description | Is this paper we present a summary of our association analyses of schizophrenia polygenic risk score with a number of phenotypes in a large cohort of people from the UK population (N=442,192). We show that individuals with higher genetic loading to schizophrenia who have not been diagnosed with neurodevelopmental disorders are likely to have some cognitive deficits. Although these deficits may be subtle, they can result in significant effects on educational attainment and professional occupation. We also show that the relationship between schizophrenia liability and fecundity is consistent with sexual selection, with liability in unaffected people being associated with a net increase in fecundity, thereby supporting the persistence of schizophrenia risk alleles. |
| first_indexed | 2024-03-12T03:01:05Z |
| format | Article |
| id | doaj.art-6321639937964849a2b9be97737881ae |
| institution | Directory Open Access Journal |
| issn | 2313-7053 2713-055X |
| language | Russian |
| last_indexed | 2024-03-12T03:01:05Z |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj.art-6321639937964849a2b9be97737881ae2023-09-03T14:46:03ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-181110.31363/2313-7053-2019-4-1-8-11270Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophreniaV. Escott-Price0Neuroscience and Mental health research institute, Dementia Research institute, Cardiff UniversityIs this paper we present a summary of our association analyses of schizophrenia polygenic risk score with a number of phenotypes in a large cohort of people from the UK population (N=442,192). We show that individuals with higher genetic loading to schizophrenia who have not been diagnosed with neurodevelopmental disorders are likely to have some cognitive deficits. Although these deficits may be subtle, they can result in significant effects on educational attainment and professional occupation. We also show that the relationship between schizophrenia liability and fecundity is consistent with sexual selection, with liability in unaffected people being associated with a net increase in fecundity, thereby supporting the persistence of schizophrenia risk alleles.https://www.bekhterevreview.com/jour/article/view/291polygenic risk score, schizophrenia, genome-wide association study |
| spellingShingle | V. Escott-Price Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева polygenic risk score, schizophrenia, genome-wide association study |
| title | Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia |
| title_full | Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia |
| title_fullStr | Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia |
| title_full_unstemmed | Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia |
| title_short | Using polygenic risk score approaches to investigate the common-variant genetic architecture of schizophrenia |
| title_sort | using polygenic risk score approaches to investigate the common variant genetic architecture of schizophrenia |
| topic | polygenic risk score, schizophrenia, genome-wide association study |
| url | https://www.bekhterevreview.com/jour/article/view/291 |
| work_keys_str_mv | AT vescottprice usingpolygenicriskscoreapproachestoinvestigatethecommonvariantgeneticarchitectureofschizophrenia |