Advances in proton therapy in lung cancer
Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-07-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753466618783878 |
| _version_ | 1817986468103061504 |
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| author | Melissa A.L. Vyfhuis Nasarachi Onyeuku Tejan Diwanji Sina Mossahebi Neha P. Amin Shahed N. Badiyan Pranshu Mohindra Charles B. Simone |
| author_facet | Melissa A.L. Vyfhuis Nasarachi Onyeuku Tejan Diwanji Sina Mossahebi Neha P. Amin Shahed N. Badiyan Pranshu Mohindra Charles B. Simone |
| author_sort | Melissa A.L. Vyfhuis |
| collection | DOAJ |
| description | Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC. |
| first_indexed | 2024-04-14T00:09:30Z |
| format | Article |
| id | doaj.art-63224f5254234bacb166d5aa1a47ff0d |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-04-14T00:09:30Z |
| publishDate | 2018-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-63224f5254234bacb166d5aa1a47ff0d2022-12-22T02:23:24ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662018-07-011210.1177/1753466618783878Advances in proton therapy in lung cancerMelissa A.L. VyfhuisNasarachi OnyeukuTejan DiwanjiSina MossahebiNeha P. AminShahed N. BadiyanPranshu MohindraCharles B. SimoneLung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC.https://doi.org/10.1177/1753466618783878 |
| spellingShingle | Melissa A.L. Vyfhuis Nasarachi Onyeuku Tejan Diwanji Sina Mossahebi Neha P. Amin Shahed N. Badiyan Pranshu Mohindra Charles B. Simone Advances in proton therapy in lung cancer Therapeutic Advances in Respiratory Disease |
| title | Advances in proton therapy in lung cancer |
| title_full | Advances in proton therapy in lung cancer |
| title_fullStr | Advances in proton therapy in lung cancer |
| title_full_unstemmed | Advances in proton therapy in lung cancer |
| title_short | Advances in proton therapy in lung cancer |
| title_sort | advances in proton therapy in lung cancer |
| url | https://doi.org/10.1177/1753466618783878 |
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