Design of enzyme-metal hybrid catalysts for organic synthesis
Summary: Enzyme-metal hybrid catalysts (EMHCs), combining the merits of both enzyme and metal catalysts with high selectivity, efficiency, and broad substrate spectrum, are potentially ideal catalysts for organic synthesis. In recent years, significant progress has been made in the design and applic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Cell Reports Physical Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666386422000066 |
| _version_ | 1818339014369869824 |
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| author | Xiaoyang Li Caicai Fu Liuqiong Luo Jun Ge |
| author_facet | Xiaoyang Li Caicai Fu Liuqiong Luo Jun Ge |
| author_sort | Xiaoyang Li |
| collection | DOAJ |
| description | Summary: Enzyme-metal hybrid catalysts (EMHCs), combining the merits of both enzyme and metal catalysts with high selectivity, efficiency, and broad substrate spectrum, are potentially ideal catalysts for organic synthesis. In recent years, significant progress has been made in the design and application of EMHCs in driving reactions that cannot be easily catalyzed by native enzymes or metals. This review summarizes recent advances in the application of EMHCs in organic synthesis. Examples of enzymatic reactions, selective chemical transformations, and chemoenzymatic cascade reactions catalyzed by biohybrid catalysts are provided, and the structure-function relationships of EMHCs are discussed. Finally, perspectives and limitations in this field are highlighted, and research directions on this exciting theme are proposed. |
| first_indexed | 2024-12-13T15:20:16Z |
| format | Article |
| id | doaj.art-63230f487a41492eb9d8f4cc8889b9b6 |
| institution | Directory Open Access Journal |
| issn | 2666-3864 |
| language | English |
| last_indexed | 2024-12-13T15:20:16Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports Physical Science |
| spelling | doaj.art-63230f487a41492eb9d8f4cc8889b9b62022-12-21T23:40:35ZengElsevierCell Reports Physical Science2666-38642022-03-0133100742Design of enzyme-metal hybrid catalysts for organic synthesisXiaoyang Li0Caicai Fu1Liuqiong Luo2Jun Ge3State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaInstitute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518107, ChinaKey Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, China; Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518107, China; Corresponding authorSummary: Enzyme-metal hybrid catalysts (EMHCs), combining the merits of both enzyme and metal catalysts with high selectivity, efficiency, and broad substrate spectrum, are potentially ideal catalysts for organic synthesis. In recent years, significant progress has been made in the design and application of EMHCs in driving reactions that cannot be easily catalyzed by native enzymes or metals. This review summarizes recent advances in the application of EMHCs in organic synthesis. Examples of enzymatic reactions, selective chemical transformations, and chemoenzymatic cascade reactions catalyzed by biohybrid catalysts are provided, and the structure-function relationships of EMHCs are discussed. Finally, perspectives and limitations in this field are highlighted, and research directions on this exciting theme are proposed.http://www.sciencedirect.com/science/article/pii/S2666386422000066organic synthesischemoenzymatic catalysishybrid catalystenzyme-metal hybrid catalyst |
| spellingShingle | Xiaoyang Li Caicai Fu Liuqiong Luo Jun Ge Design of enzyme-metal hybrid catalysts for organic synthesis Cell Reports Physical Science organic synthesis chemoenzymatic catalysis hybrid catalyst enzyme-metal hybrid catalyst |
| title | Design of enzyme-metal hybrid catalysts for organic synthesis |
| title_full | Design of enzyme-metal hybrid catalysts for organic synthesis |
| title_fullStr | Design of enzyme-metal hybrid catalysts for organic synthesis |
| title_full_unstemmed | Design of enzyme-metal hybrid catalysts for organic synthesis |
| title_short | Design of enzyme-metal hybrid catalysts for organic synthesis |
| title_sort | design of enzyme metal hybrid catalysts for organic synthesis |
| topic | organic synthesis chemoenzymatic catalysis hybrid catalyst enzyme-metal hybrid catalyst |
| url | http://www.sciencedirect.com/science/article/pii/S2666386422000066 |
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