Does L-carnitine improve endothelial function in hemodialysis patients?
Background: Atherosclerosis is the leading cause of death in hemodialysis patients. These patients are also very prone to L-carnitine deficiency due to kidney disease. In this clinical trial, we investigated the effect of oral L-carnitine on endothelial function of these patients. Materials ans Meth...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=5;spage=417;epage=421;aulast=Sabri |
| _version_ | 1818315527918977024 |
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| author | Mohammad Reza Sabri Farnaz Fahimi Soheila Hajialiasgar Abbas Etminan Sarir Nazemi Farzaneh Salehi |
| author_facet | Mohammad Reza Sabri Farnaz Fahimi Soheila Hajialiasgar Abbas Etminan Sarir Nazemi Farzaneh Salehi |
| author_sort | Mohammad Reza Sabri |
| collection | DOAJ |
| description | Background: Atherosclerosis is the leading cause of death in hemodialysis patients. These patients are also very prone to L-carnitine deficiency due to kidney disease. In this clinical trial, we investigated the effect of oral L-carnitine on endothelial function of these patients. Materials ans Methods : We studied 31 adult chronic hemodialysis patients in our center and divided them into two groups. The first group (n = 20) received 1500 mg/dialysis interval (every other day) oral L-carnitine. The control group (n = 11) received placebo for one month. Ultrasonographic measurements of flow mediated dilation and carotid intima-media thickness were performed before and after one month of L-carnitine and placebo therapy. Results: This study showed that after one month of L-carnitine or placebo therapy there was no significant improvement in flow mediated dilation (p = 0.80 and p = 0.59, respectively) or decrease in carotid intima-media thickness (p = 0.12 and p = 0.50, respectively). Conclusions: Our study revealed that one month of oral L-carnitine therapy did not improve endothelial function in hemodialysis patients. Long-term studies with large sample size using intravenous form and higher doses of the drug are required to clarify the questionable role of L-carnitine in hemodialysis patients. |
| first_indexed | 2024-12-13T09:06:58Z |
| format | Article |
| id | doaj.art-632395c933394735a21c60819e28f6b8 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-13T09:06:58Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-632395c933394735a21c60819e28f6b82022-12-21T23:53:03ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362012-01-01175417421Does L-carnitine improve endothelial function in hemodialysis patients?Mohammad Reza SabriFarnaz FahimiSoheila HajialiasgarAbbas EtminanSarir NazemiFarzaneh SalehiBackground: Atherosclerosis is the leading cause of death in hemodialysis patients. These patients are also very prone to L-carnitine deficiency due to kidney disease. In this clinical trial, we investigated the effect of oral L-carnitine on endothelial function of these patients. Materials ans Methods : We studied 31 adult chronic hemodialysis patients in our center and divided them into two groups. The first group (n = 20) received 1500 mg/dialysis interval (every other day) oral L-carnitine. The control group (n = 11) received placebo for one month. Ultrasonographic measurements of flow mediated dilation and carotid intima-media thickness were performed before and after one month of L-carnitine and placebo therapy. Results: This study showed that after one month of L-carnitine or placebo therapy there was no significant improvement in flow mediated dilation (p = 0.80 and p = 0.59, respectively) or decrease in carotid intima-media thickness (p = 0.12 and p = 0.50, respectively). Conclusions: Our study revealed that one month of oral L-carnitine therapy did not improve endothelial function in hemodialysis patients. Long-term studies with large sample size using intravenous form and higher doses of the drug are required to clarify the questionable role of L-carnitine in hemodialysis patients.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=5;spage=417;epage=421;aulast=SabriFlow Mediated DilationCarotid Intima-Media ThicknessEndothelial DysfunctionChronic Renal FailureL-Carnitine. |
| spellingShingle | Mohammad Reza Sabri Farnaz Fahimi Soheila Hajialiasgar Abbas Etminan Sarir Nazemi Farzaneh Salehi Does L-carnitine improve endothelial function in hemodialysis patients? Journal of Research in Medical Sciences Flow Mediated Dilation Carotid Intima-Media Thickness Endothelial Dysfunction Chronic Renal Failure L-Carnitine. |
| title | Does L-carnitine improve endothelial function in hemodialysis patients? |
| title_full | Does L-carnitine improve endothelial function in hemodialysis patients? |
| title_fullStr | Does L-carnitine improve endothelial function in hemodialysis patients? |
| title_full_unstemmed | Does L-carnitine improve endothelial function in hemodialysis patients? |
| title_short | Does L-carnitine improve endothelial function in hemodialysis patients? |
| title_sort | does l carnitine improve endothelial function in hemodialysis patients |
| topic | Flow Mediated Dilation Carotid Intima-Media Thickness Endothelial Dysfunction Chronic Renal Failure L-Carnitine. |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2012;volume=17;issue=5;spage=417;epage=421;aulast=Sabri |
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