CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups
Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks. Materials and methods. The study involved 400 volunteers from four ethnic groups living in Republi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2021-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/99612/73074 |
| _version_ | 1818282495164022784 |
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| author | Sherzod P. Abdullaev Natalia P. Denisenko Karin B. Mirzaev Gregorii N. Shuev Zhannet A. Sozaeva Anastasia A. Kachanova Suleiman N. Mammaev Elvira A. Kasaeva Danial M. Gafurov Elena A. Grishina Dmitry A. Sychev |
| author_facet | Sherzod P. Abdullaev Natalia P. Denisenko Karin B. Mirzaev Gregorii N. Shuev Zhannet A. Sozaeva Anastasia A. Kachanova Suleiman N. Mammaev Elvira A. Kasaeva Danial M. Gafurov Elena A. Grishina Dmitry A. Sychev |
| author_sort | Sherzod P. Abdullaev |
| collection | DOAJ |
| description | Aim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks.
Materials and methods. The study involved 400 volunteers from four ethnic groups living in Republic of Dagestan: 100 participants from each group. Carriage of polymorphic markers was determined by reverse transcription polymerase chain reaction.
Results. Minor allele frequency of the CYP2C8 (rs10509681) was 5.5% in Avars, 10% in Dargins, Laks and Kumyks 6.5% both; CYP2C8 (rs11572080) was 5.5% in Avars, 9.5% in Dargins, 6.5% in Laks, 8.5% in Kumyks; PTGS-1 (rs10306135) in Avars 10.5%, in Dargins 13.0%, in Laks 9.5% and Kumyks 7.5%; PTGS-1 (rs12353214) in Avars 9.0%, in Dargins 4.5%, in Laks 7.5%, in Kumyks 8.0%; PTGS-2 (rs20417) in Avars 1.0%, in Dargins 2.5%, in Laks 3.5%, in Kumyks 5.0%. There were no significant differences between groups.
Conclusion. The study of CYP2C8 and PTGS-1 and 2 gene polymorphisms is promising for predicting the effectiveness and safety of non-steroidal anti-inflammatory drug therapy, due to the high prevalence of these polymorphisms in ethnic groups in the North Caucasus. |
| first_indexed | 2024-12-13T00:21:55Z |
| format | Article |
| id | doaj.art-6327540a6a154855b37743fb9d3ef1d7 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T00:21:55Z |
| publishDate | 2021-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-6327540a6a154855b37743fb9d3ef1d72022-12-22T00:05:33Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422021-11-0193111334133910.26442/00403660.2021.11.20122078028CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groupsSherzod P. Abdullaev0https://orcid.org/0000-0001-9001-1499Natalia P. Denisenko1https://orcid.org/0000-0003-3278-5941Karin B. Mirzaev2https://orcid.org/0000-0002-9307-4994Gregorii N. Shuev3https://orcid.org/0000-0002-5031-0088Zhannet A. Sozaeva4https://orcid.org/0000-0001-5166-7903Anastasia A. Kachanova5https://orcid.org/0000-0003-3194-4410Suleiman N. Mammaev6https://orcid.org/0000-0001-8898-8831Elvira A. Kasaeva7https://orcid.org/0000-0003-0234-0597Danial M. Gafurov8https://orcid.org/0000-0002-8321-9176Elena A. Grishina9https://orcid.org/0000-0002-5621-8266Dmitry A. Sychev10https://orcid.org/0000-0002-4496-3680Russian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationDagestan State Medical UniversityDagestan State Medical UniversityRepublican Cardiological DispensaryRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationAim. Find the prevalence of CYP2C8*3 (rs10509681; rs11572080), PTGS-1 (rs10306135; rs12353214) and PTGS-2 (rs20417) alleles and genotypes in four ethnic groups among Laks, Avars, Dargins and Kumyks. Materials and methods. The study involved 400 volunteers from four ethnic groups living in Republic of Dagestan: 100 participants from each group. Carriage of polymorphic markers was determined by reverse transcription polymerase chain reaction. Results. Minor allele frequency of the CYP2C8 (rs10509681) was 5.5% in Avars, 10% in Dargins, Laks and Kumyks 6.5% both; CYP2C8 (rs11572080) was 5.5% in Avars, 9.5% in Dargins, 6.5% in Laks, 8.5% in Kumyks; PTGS-1 (rs10306135) in Avars 10.5%, in Dargins 13.0%, in Laks 9.5% and Kumyks 7.5%; PTGS-1 (rs12353214) in Avars 9.0%, in Dargins 4.5%, in Laks 7.5%, in Kumyks 8.0%; PTGS-2 (rs20417) in Avars 1.0%, in Dargins 2.5%, in Laks 3.5%, in Kumyks 5.0%. There were no significant differences between groups. Conclusion. The study of CYP2C8 and PTGS-1 and 2 gene polymorphisms is promising for predicting the effectiveness and safety of non-steroidal anti-inflammatory drug therapy, due to the high prevalence of these polymorphisms in ethnic groups in the North Caucasus.https://ter-arkhiv.ru/0040-3660/article/viewFile/99612/73074pharmacogeneticsethnicscyp2c8ptgs-1ptgs-2non-steroidal anti-inflammatory drugs |
| spellingShingle | Sherzod P. Abdullaev Natalia P. Denisenko Karin B. Mirzaev Gregorii N. Shuev Zhannet A. Sozaeva Anastasia A. Kachanova Suleiman N. Mammaev Elvira A. Kasaeva Danial M. Gafurov Elena A. Grishina Dmitry A. Sychev CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups Терапевтический архив pharmacogenetics ethnics cyp2c8 ptgs-1 ptgs-2 non-steroidal anti-inflammatory drugs |
| title | CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups |
| title_full | CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups |
| title_fullStr | CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups |
| title_full_unstemmed | CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups |
| title_short | CYP2C8, PTGS-1, 2 gene polymorphisms prevalence associated with sensitivity to non-steroidal anti-inflammatory drugs among North Caucasus ethnic groups |
| title_sort | cyp2c8 ptgs 1 2 gene polymorphisms prevalence associated with sensitivity to non steroidal anti inflammatory drugs among north caucasus ethnic groups |
| topic | pharmacogenetics ethnics cyp2c8 ptgs-1 ptgs-2 non-steroidal anti-inflammatory drugs |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/99612/73074 |
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