Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients
We investigated the associations of ten previously identified high risk molecular lipid species and three ceramide ratios with the occurrence of major adverse cardiac events (MACEs) during a median follow-up of 4.7 years in patients with coronary artery disease (CAD). Between 2008 and 2011, 581 pati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520335410 |
| _version_ | 1818605854515003392 |
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| author | Sharda Anroedh Mika Hilvo K. Martijn Akkerhuis Dimple Kauhanen Kaisa Koistinen Rohit Oemrawsingh Patrick Serruys Robert-Jan van Geuns Eric Boersma Reijo Laaksonen Isabella Kardys |
| author_facet | Sharda Anroedh Mika Hilvo K. Martijn Akkerhuis Dimple Kauhanen Kaisa Koistinen Rohit Oemrawsingh Patrick Serruys Robert-Jan van Geuns Eric Boersma Reijo Laaksonen Isabella Kardys |
| author_sort | Sharda Anroedh |
| collection | DOAJ |
| description | We investigated the associations of ten previously identified high risk molecular lipid species and three ceramide ratios with the occurrence of major adverse cardiac events (MACEs) during a median follow-up of 4.7 years in patients with coronary artery disease (CAD). Between 2008 and 2011, 581 patients underwent diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris (SAP) or acute coronary syndrome (ACS). Blood was drawn prior to the index procedure and lipid species were determined. The primary endpoint was the occurrence of a MACE, comprising all-cause mortality, nonfatal ACS, or unplanned coronary revascularization. The secondary endpoint comprised all-cause mortality or nonfatal ACS. During a median follow-up of 4.7 [IQR: 4.2–5.6] years, 155 patients (27%) had MACEs. In multivariable analyses, Cer(d18:1/16:0) concentration was associated with MACEs {hazard ratio 2.32; 95% CI [1.09–4.96] per natural logarithm (ln) (pmol/ml) P = 0.030} after adjustment for cardiac risk factors, clinical presentation, statin use at baseline, and admission nonHDL cholesterol level. Furthermore, after multivariable adjustment, concentrations of Cer(d18:1/16:0), Cer(d18:1/20:0), Cer(d18:1/24:1), and their ratios to Cer(d18:1/24:0) were associated with the composite endpoint death or nonfatal ACS. The data together show the circulating ceramide lipids we investigated here are associated with adverse cardiac outcome during long-term follow-up independent of clinical risk factors. |
| first_indexed | 2024-12-16T14:01:35Z |
| format | Article |
| id | doaj.art-63278f3a40ac454cb7f424bcf0ec8fe7 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T14:01:35Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-63278f3a40ac454cb7f424bcf0ec8fe72022-12-21T22:29:03ZengElsevierJournal of Lipid Research0022-22752018-09-0159917291737Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patientsSharda Anroedh0Mika Hilvo1K. Martijn Akkerhuis2Dimple Kauhanen3Kaisa Koistinen4Rohit Oemrawsingh5Patrick Serruys6Robert-Jan van Geuns7Eric Boersma8Reijo Laaksonen9Isabella Kardys10Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The NetherlandsZora Biosciences Oy, Espoo, FinlandDepartment of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The NetherlandsZora Biosciences Oy, Espoo, FinlandZora Biosciences Oy, Espoo, FinlandDepartment of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The NetherlandsFaculty of Medicine, National Heart & Lung Institute, Imperial College London, London, United KingdomDepartment of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The NetherlandsZora Biosciences Oy, Espoo, Finland; Finnish Cardiovascular Research Center Tampere, University of Tampere, Tampere, Finland and Finnish Clinical Biobank Tampere, University Hospital of Tampere, Tampere Finland; andTo whom correspondence should be addressed.; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands; Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The NetherlandsWe investigated the associations of ten previously identified high risk molecular lipid species and three ceramide ratios with the occurrence of major adverse cardiac events (MACEs) during a median follow-up of 4.7 years in patients with coronary artery disease (CAD). Between 2008 and 2011, 581 patients underwent diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris (SAP) or acute coronary syndrome (ACS). Blood was drawn prior to the index procedure and lipid species were determined. The primary endpoint was the occurrence of a MACE, comprising all-cause mortality, nonfatal ACS, or unplanned coronary revascularization. The secondary endpoint comprised all-cause mortality or nonfatal ACS. During a median follow-up of 4.7 [IQR: 4.2–5.6] years, 155 patients (27%) had MACEs. In multivariable analyses, Cer(d18:1/16:0) concentration was associated with MACEs {hazard ratio 2.32; 95% CI [1.09–4.96] per natural logarithm (ln) (pmol/ml) P = 0.030} after adjustment for cardiac risk factors, clinical presentation, statin use at baseline, and admission nonHDL cholesterol level. Furthermore, after multivariable adjustment, concentrations of Cer(d18:1/16:0), Cer(d18:1/20:0), Cer(d18:1/24:1), and their ratios to Cer(d18:1/24:0) were associated with the composite endpoint death or nonfatal ACS. The data together show the circulating ceramide lipids we investigated here are associated with adverse cardiac outcome during long-term follow-up independent of clinical risk factors.http://www.sciencedirect.com/science/article/pii/S0022227520335410lipidomicsceramidesheartatherosclerosisvascular biologyfollow-up |
| spellingShingle | Sharda Anroedh Mika Hilvo K. Martijn Akkerhuis Dimple Kauhanen Kaisa Koistinen Rohit Oemrawsingh Patrick Serruys Robert-Jan van Geuns Eric Boersma Reijo Laaksonen Isabella Kardys Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients Journal of Lipid Research lipidomics ceramides heart atherosclerosis vascular biology follow-up |
| title | Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients |
| title_full | Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients |
| title_fullStr | Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients |
| title_full_unstemmed | Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients |
| title_short | Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients |
| title_sort | plasma concentrations of molecular lipid species predict long term clinical outcome in coronary artery disease patients |
| topic | lipidomics ceramides heart atherosclerosis vascular biology follow-up |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520335410 |
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