Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study
Abstract. Introduction:. We recently showed that the psycho-stimulant norepinephrine–dopamine reuptake inhibitor methylphenidate (MP) prolonged cold pain threshold and tolerance in adults with attention-deficit hyperactivity disorder (ADHD). Objectives:. The objectives of the present study were to:...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2017-06-01
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| Series: | PAIN Reports |
| Online Access: | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000593 |
| _version_ | 1818113156654825472 |
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| author | Dorit Pud Eelena Broitman Omar Hameed Erica Suzan Joshua Aviram May Haddad Salim Hadad Rafi Shemesh Elon Eisenberg |
| author_facet | Dorit Pud Eelena Broitman Omar Hameed Erica Suzan Joshua Aviram May Haddad Salim Hadad Rafi Shemesh Elon Eisenberg |
| author_sort | Dorit Pud |
| collection | DOAJ |
| description | Abstract. Introduction:. We recently showed that the psycho-stimulant norepinephrine–dopamine reuptake inhibitor methylphenidate (MP) prolonged cold pain threshold and tolerance in adults with attention-deficit hyperactivity disorder (ADHD).
Objectives:. The objectives of the present study were to: (1) examine whether MP has antinociceptive properties in healthy men; (2) test MP's effects on responses to aversive auditory stimuli. The underlying aim was to determine whether MP exerts antinociceptive properties or more generalized, nonspecific attenuating effects on different aversive sensory modalities.
Methods:. This double-blind, crossover, randomized placebo-controlled study consisted of 2 sessions one week apart from each other. In each session, pain threshold (seconds) and tolerance (seconds) in response to painful cold stimulation were measured. Additionally, threshold (dB) and tolerance (seconds) to loud aversive auditory stimuli (500 Hz, 2000 Hz and white noise) were also tested prior to and 2 hours following the administration of a single dose of either 20 mg MP or an identical looking placebo.
Results:. Forty men, 26.1 ± 4.0 (mean ± SD) years were enrolled in the study. Wilcoxon signed-rank test analyses showed that MP, but not the placebo, produced a significant increase in cold pain threshold (from 4.1 ± 2.6 to 5.4 ± 3.1 seconds, P = 0.001 and from 4.5 ± 2.6 to 4.3 ± 2.7 seconds, P = 0.2, respectively) and tolerance (from 57.8 ± 54.0 to 73.8 ± 61.8 seconds, P = 0.001 and from 52.5 ± 53.7 sec to 57.0 ± 52.9 seconds, P = 0.1, respectively). No significant changes were found in any of the auditory parameters.
Conclusion:. These results suggest that MP has an effect on nociceptive pathways rather than a nonspecific, generalized attenuating effect on aversive sensory stimuli. |
| first_indexed | 2024-12-11T03:30:21Z |
| format | Article |
| id | doaj.art-6329c29877184918952088f2bf6508d1 |
| institution | Directory Open Access Journal |
| issn | 2471-2531 |
| language | English |
| last_indexed | 2024-12-11T03:30:21Z |
| publishDate | 2017-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | PAIN Reports |
| spelling | doaj.art-6329c29877184918952088f2bf6508d12022-12-22T01:22:24ZengWolters KluwerPAIN Reports2471-25312017-06-0123e59310.1097/PR9.0000000000000593201706000-00011Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled studyDorit Pud0Eelena Broitman1Omar Hameed2Erica Suzan3Joshua Aviram4May Haddad5Salim Hadad6Rafi Shemesh7Elon Eisenberg8aDepartment of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, IsraelaDepartment of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, IsraelbDepartment of Communication Sciences and Disorders, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, IsraelcThe Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, IsraelaDepartment of Nursing, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, IsraeldInstitute of Pain Medicine, Rambam Health Care Campus, Haifa, IsraeleDepartment of Pharmacy, Rambam Health Care Campus, Haifa, IsraelbDepartment of Communication Sciences and Disorders, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, IsraelcThe Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa, IsraelAbstract. Introduction:. We recently showed that the psycho-stimulant norepinephrine–dopamine reuptake inhibitor methylphenidate (MP) prolonged cold pain threshold and tolerance in adults with attention-deficit hyperactivity disorder (ADHD). Objectives:. The objectives of the present study were to: (1) examine whether MP has antinociceptive properties in healthy men; (2) test MP's effects on responses to aversive auditory stimuli. The underlying aim was to determine whether MP exerts antinociceptive properties or more generalized, nonspecific attenuating effects on different aversive sensory modalities. Methods:. This double-blind, crossover, randomized placebo-controlled study consisted of 2 sessions one week apart from each other. In each session, pain threshold (seconds) and tolerance (seconds) in response to painful cold stimulation were measured. Additionally, threshold (dB) and tolerance (seconds) to loud aversive auditory stimuli (500 Hz, 2000 Hz and white noise) were also tested prior to and 2 hours following the administration of a single dose of either 20 mg MP or an identical looking placebo. Results:. Forty men, 26.1 ± 4.0 (mean ± SD) years were enrolled in the study. Wilcoxon signed-rank test analyses showed that MP, but not the placebo, produced a significant increase in cold pain threshold (from 4.1 ± 2.6 to 5.4 ± 3.1 seconds, P = 0.001 and from 4.5 ± 2.6 to 4.3 ± 2.7 seconds, P = 0.2, respectively) and tolerance (from 57.8 ± 54.0 to 73.8 ± 61.8 seconds, P = 0.001 and from 52.5 ± 53.7 sec to 57.0 ± 52.9 seconds, P = 0.1, respectively). No significant changes were found in any of the auditory parameters. Conclusion:. These results suggest that MP has an effect on nociceptive pathways rather than a nonspecific, generalized attenuating effect on aversive sensory stimuli.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000593 |
| spellingShingle | Dorit Pud Eelena Broitman Omar Hameed Erica Suzan Joshua Aviram May Haddad Salim Hadad Rafi Shemesh Elon Eisenberg Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study PAIN Reports |
| title | Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study |
| title_full | Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study |
| title_fullStr | Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study |
| title_full_unstemmed | Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study |
| title_short | Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study |
| title_sort | methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human a double blind randomized controlled study |
| url | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000593 |
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