Cyclic Peptide-Based Sirtuin Substrates
In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N<sup>ε</sup>-acetyl-lysine or N<sup>ε</sup>-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with go...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/3/424 |
| _version_ | 1818248591715598336 |
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| author | Di Chen Lingling Yan Weiping Zheng |
| author_facet | Di Chen Lingling Yan Weiping Zheng |
| author_sort | Di Chen |
| collection | DOAJ |
| description | In the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N<sup>ε</sup>-acetyl-lysine or N<sup>ε</sup>-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the <i>k</i><sub>cat</sub>/<i>K</i><sub>M</sub> ratios. |
| first_indexed | 2024-12-12T15:23:02Z |
| format | Article |
| id | doaj.art-632a434626984ec6bc6ed0e33edd8944 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T15:23:02Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-632a434626984ec6bc6ed0e33edd89442022-12-22T00:20:20ZengMDPI AGMolecules1420-30492019-01-0124342410.3390/molecules24030424molecules24030424Cyclic Peptide-Based Sirtuin SubstratesDi Chen0Lingling Yan1Weiping Zheng2School of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, ChinaSchool of Pharmacy, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, ChinaIn the current study, four side chain-to-side chain cyclic peptides (three 5-mers and one 4-mer) harboring N<sup>ε</sup>-acetyl-lysine or N<sup>ε</sup>-myristoyl-lysine were found to be in vitro substrates of the human SIRT1/2/3-catalyzed deacylation with good substrate activities, as judged by the <i>k</i><sub>cat</sub>/<i>K</i><sub>M</sub> ratios.https://www.mdpi.com/1420-3049/24/3/424sirtuindeacylationsubstratecyclic peptide |
| spellingShingle | Di Chen Lingling Yan Weiping Zheng Cyclic Peptide-Based Sirtuin Substrates Molecules sirtuin deacylation substrate cyclic peptide |
| title | Cyclic Peptide-Based Sirtuin Substrates |
| title_full | Cyclic Peptide-Based Sirtuin Substrates |
| title_fullStr | Cyclic Peptide-Based Sirtuin Substrates |
| title_full_unstemmed | Cyclic Peptide-Based Sirtuin Substrates |
| title_short | Cyclic Peptide-Based Sirtuin Substrates |
| title_sort | cyclic peptide based sirtuin substrates |
| topic | sirtuin deacylation substrate cyclic peptide |
| url | https://www.mdpi.com/1420-3049/24/3/424 |
| work_keys_str_mv | AT dichen cyclicpeptidebasedsirtuinsubstrates AT linglingyan cyclicpeptidebasedsirtuinsubstrates AT weipingzheng cyclicpeptidebasedsirtuinsubstrates |