Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency

Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency

Human pluripotent stem cells (hPSCs) have been reported in naive and primed states. However, the ability to generate mature cell types remains the imperative property for utility of hPSCs. Here, we reveal that the naive state enhances self-renewal while restricting lineage differentiation in vitro t...

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Bibliographic Details
Main Authors: Jong-Hee Lee, Sarah Laronde, Tony J. Collins, Zoya Shapovalova, Borko Tanasijevic, Jamie D. McNicol, Aline Fiebig-Comyn, Yannick D. Benoit, Jung Bok Lee, Ryan R. Mitchell, Mickie Bhatia
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
human pluripotency
naïve state
differentiation
reprogramming
lineage specification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303686

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