Transposable element-derived sequences in vertebrate development
Abstract Transposable elements (TEs) are major components of all vertebrate genomes that can cause deleterious insertions and genomic instability. However, depending on the specific genomic context of their insertion site, TE sequences can sometimes get positively selected, leading to what are calle...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Mobile DNA |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13100-020-00229-5 |
| _version_ | 1819278999558291456 |
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| author | Ema Etchegaray Magali Naville Jean-Nicolas Volff Zofia Haftek-Terreau |
| author_facet | Ema Etchegaray Magali Naville Jean-Nicolas Volff Zofia Haftek-Terreau |
| author_sort | Ema Etchegaray |
| collection | DOAJ |
| description | Abstract Transposable elements (TEs) are major components of all vertebrate genomes that can cause deleterious insertions and genomic instability. However, depending on the specific genomic context of their insertion site, TE sequences can sometimes get positively selected, leading to what are called “exaptation” events. TE sequence exaptation constitutes an important source of novelties for gene, genome and organism evolution, giving rise to new regulatory sequences, protein-coding exons/genes and non-coding RNAs, which can play various roles beneficial to the host. In this review, we focus on the development of vertebrates, which present many derived traits such as bones, adaptive immunity and a complex brain. We illustrate how TE-derived sequences have given rise to developmental innovations in vertebrates and how they thereby contributed to the evolutionary success of this lineage. |
| first_indexed | 2024-12-24T00:20:56Z |
| format | Article |
| id | doaj.art-632efc4e97f240b0a7efcfacadbf55ab |
| institution | Directory Open Access Journal |
| issn | 1759-8753 |
| language | English |
| last_indexed | 2024-12-24T00:20:56Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Mobile DNA |
| spelling | doaj.art-632efc4e97f240b0a7efcfacadbf55ab2022-12-21T17:24:35ZengBMCMobile DNA1759-87532021-01-0112112410.1186/s13100-020-00229-5Transposable element-derived sequences in vertebrate developmentEma Etchegaray0Magali Naville1Jean-Nicolas Volff2Zofia Haftek-Terreau3Institut de Genomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1Institut de Genomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1Institut de Genomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1Institut de Genomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1Abstract Transposable elements (TEs) are major components of all vertebrate genomes that can cause deleterious insertions and genomic instability. However, depending on the specific genomic context of their insertion site, TE sequences can sometimes get positively selected, leading to what are called “exaptation” events. TE sequence exaptation constitutes an important source of novelties for gene, genome and organism evolution, giving rise to new regulatory sequences, protein-coding exons/genes and non-coding RNAs, which can play various roles beneficial to the host. In this review, we focus on the development of vertebrates, which present many derived traits such as bones, adaptive immunity and a complex brain. We illustrate how TE-derived sequences have given rise to developmental innovations in vertebrates and how they thereby contributed to the evolutionary success of this lineage.https://doi.org/10.1186/s13100-020-00229-5Transposable elementsVertebratesDevelopmentGenetic innovationExaptationGenome evolution |
| spellingShingle | Ema Etchegaray Magali Naville Jean-Nicolas Volff Zofia Haftek-Terreau Transposable element-derived sequences in vertebrate development Mobile DNA Transposable elements Vertebrates Development Genetic innovation Exaptation Genome evolution |
| title | Transposable element-derived sequences in vertebrate development |
| title_full | Transposable element-derived sequences in vertebrate development |
| title_fullStr | Transposable element-derived sequences in vertebrate development |
| title_full_unstemmed | Transposable element-derived sequences in vertebrate development |
| title_short | Transposable element-derived sequences in vertebrate development |
| title_sort | transposable element derived sequences in vertebrate development |
| topic | Transposable elements Vertebrates Development Genetic innovation Exaptation Genome evolution |
| url | https://doi.org/10.1186/s13100-020-00229-5 |
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