Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients
There has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/7/376 |
| _version_ | 1797440060542418944 |
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| author | Cheryl Duzenli Elisa K. Chan Theodora Koulis Sheri Grahame Joel Singer David Morris Josslynn Spence Terry Lee Levi Burns Robert A. Olson |
| author_facet | Cheryl Duzenli Elisa K. Chan Theodora Koulis Sheri Grahame Joel Singer David Morris Josslynn Spence Terry Lee Levi Burns Robert A. Olson |
| author_sort | Cheryl Duzenli |
| collection | DOAJ |
| description | There has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute breast skin toxicity PRO measure across a broad sample of patient body types undergoing radiation therapy. Between August 2018 and September 2019, 134 women undergoing adjuvant breast radiotherapy (RT) consented to completing serial PRO measures both during and post-RT treatment and to having their skin assessed by trained trial radiation therapists. There was high patient compliance, with 124 patients (92.5%) returning to the clinic post-RT for at least one staff skin assessment. Rates of moist desquamation (MD) in the infra-mammary fold (IMF) by PRO were compared with skin assessments completed by trial radiation therapists. There was high sensitivity (86.5%) and good specificity (79.4%) between PRO and staff-reported presence of MD in the IMF, and there was a moderate correlation between the peak severity of the MD reported by PRO and assessed by staff (rho = 0.61, <i>p</i> < 0.001). This prospective study validates a new PRO measure to monitor the presence of MD in the IMF among women receiving breast RT. |
| first_indexed | 2024-03-09T12:02:42Z |
| format | Article |
| id | doaj.art-632f46c92e1e4e5295212c4fd13f7b7b |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T12:02:42Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-632f46c92e1e4e5295212c4fd13f7b7b2023-11-30T23:02:02ZengMDPI AGCurrent Oncology1198-00521718-77292022-07-012974734474710.3390/curroncol29070376Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy PatientsCheryl Duzenli0Elisa K. Chan1Theodora Koulis2Sheri Grahame3Joel Singer4David Morris5Josslynn Spence6Terry Lee7Levi Burns8Robert A. Olson9Department of Medical Physics, BC Cancer, Vancouver, BC V5Z 4E6, CanadaDepartment of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, CanadaDepartment of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, CanadaDepartment of Radiation Therapy, BC Cancer, Vancouver, BC V5Z 4E6, CanadaSchool of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, CanadaDepartment of Radiation Therapy, BC Cancer, Prince George, BC V2M 7E9, CanadaDepartment of Radiation Therapy, BC Cancer, Prince George, BC V2M 7E9, CanadaCentre for Health Evaluation and Outcome Sciences, St. Paul’s Hospital, Vancouver, BC V6Z 1Y6, CanadaMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON L8S 4L8, CanadaDepartment of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, CanadaThere has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute breast skin toxicity PRO measure across a broad sample of patient body types undergoing radiation therapy. Between August 2018 and September 2019, 134 women undergoing adjuvant breast radiotherapy (RT) consented to completing serial PRO measures both during and post-RT treatment and to having their skin assessed by trained trial radiation therapists. There was high patient compliance, with 124 patients (92.5%) returning to the clinic post-RT for at least one staff skin assessment. Rates of moist desquamation (MD) in the infra-mammary fold (IMF) by PRO were compared with skin assessments completed by trial radiation therapists. There was high sensitivity (86.5%) and good specificity (79.4%) between PRO and staff-reported presence of MD in the IMF, and there was a moderate correlation between the peak severity of the MD reported by PRO and assessed by staff (rho = 0.61, <i>p</i> < 0.001). This prospective study validates a new PRO measure to monitor the presence of MD in the IMF among women receiving breast RT.https://www.mdpi.com/1718-7729/29/7/376breast cancerbreast radiotherapyskin toxicitymoist desquamationpatient-reported outcomesradiation dermatitis |
| spellingShingle | Cheryl Duzenli Elisa K. Chan Theodora Koulis Sheri Grahame Joel Singer David Morris Josslynn Spence Terry Lee Levi Burns Robert A. Olson Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients Current Oncology breast cancer breast radiotherapy skin toxicity moist desquamation patient-reported outcomes radiation dermatitis |
| title | Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients |
| title_full | Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients |
| title_fullStr | Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients |
| title_full_unstemmed | Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients |
| title_short | Validation of a Patient-Reported Outcome Measure for Moist Desquamation among Breast Radiotherapy Patients |
| title_sort | validation of a patient reported outcome measure for moist desquamation among breast radiotherapy patients |
| topic | breast cancer breast radiotherapy skin toxicity moist desquamation patient-reported outcomes radiation dermatitis |
| url | https://www.mdpi.com/1718-7729/29/7/376 |
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