Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5416 |
| _version_ | 1797512709463343104 |
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| author | Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios |
| author_facet | Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios |
| author_sort | Silvia González-Martínez |
| collection | DOAJ |
| description | Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined. Here, we review the main clinical, pathological, and molecular characteristics of breast cancer CMs. Identifying molecular markers in primary BC that predict CM and can be used to determine the molecular differences between primary tumors and their metastases is of great interest for the design of new therapeutic approaches. |
| first_indexed | 2024-03-10T06:05:32Z |
| format | Article |
| id | doaj.art-633030240f00426e8b275e87abb0fd03 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:05:32Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-633030240f00426e8b275e87abb0fd032023-11-22T20:34:56ZengMDPI AGCancers2072-66942021-10-011321541610.3390/cancers13215416Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous MetastasisSilvia González-Martínez0David Pizarro1Belén Pérez-Mies2Tamara Caniego-Casas3Giuseppe Curigliano4Javier Cortés5José Palacios6Clinical Researcher, Hospital Ramón y Cajal, 28034 Madrid, SpainDepartment of Pathology, Hospital Ramón y Cajal, 28034 Madrid, SpainDepartment of Pathology, Hospital Ramón y Cajal, 28034 Madrid, SpainDepartment of Pathology, Hospital Ramón y Cajal, 28034 Madrid, SpainEuropean Institute of Oncology, IRCCS, 20141 Milan, ItalyCIBER-ONC, Instituto de Salud Carlos III, 28029 Madrid, SpainDepartment of Pathology, Hospital Ramón y Cajal, 28034 Madrid, SpainCutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined. Here, we review the main clinical, pathological, and molecular characteristics of breast cancer CMs. Identifying molecular markers in primary BC that predict CM and can be used to determine the molecular differences between primary tumors and their metastases is of great interest for the design of new therapeutic approaches.https://www.mdpi.com/2072-6694/13/21/5416breast cancermetastasisskinpathologyimmunohistochemistrymutation |
| spellingShingle | Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis Cancers breast cancer metastasis skin pathology immunohistochemistry mutation |
| title | Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis |
| title_full | Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis |
| title_fullStr | Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis |
| title_full_unstemmed | Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis |
| title_short | Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis |
| title_sort | clinical pathological and molecular features of breast carcinoma cutaneous metastasis |
| topic | breast cancer metastasis skin pathology immunohistochemistry mutation |
| url | https://www.mdpi.com/2072-6694/13/21/5416 |
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