Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food
Various gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects...
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5143 |
| _version_ | 1797504344001609728 |
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| author | Carmen Ranftler Andreas Röhrich Andreas Sparer Cornelius Tschegg Dietmar Nagl |
| author_facet | Carmen Ranftler Andreas Röhrich Andreas Sparer Cornelius Tschegg Dietmar Nagl |
| author_sort | Carmen Ranftler |
| collection | DOAJ |
| description | Various gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects are induced by wheat, barley, and rye. The only treatment is based on the absolute avoidance of those foods, as even traces might have severe effects on human well-being. With the goal of binding gluten impurities after ingestion, an in vitro setting was created. A special processed kind of zeolite, purified clinoptilolite-tuff (PCT), was implemented as an adsorber of gluten derived from different origins. Zeolites are known for their excellent sorption capacities and their applications in humans and animals have been studied for a long time. Tests were also performed in artificial gastric and intestinal fluids, and the adsorption capacity was determined via a certified validated method (ELISA). Depending on the kind of gluten source, 80–130 µg/mg of gluten were bound onto PCT. Hence, purified clinoptilolite-tuff, which was successfully tested for wheat, barley, and rye, proved to be suitable for the adsorption of gluten originating from different kinds of crops. This result might form the basis for an expedient human study in the future. |
| first_indexed | 2024-03-10T04:03:18Z |
| format | Article |
| id | doaj.art-63305f919365498cb538dbb43597d2bb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:03:18Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-63305f919365498cb538dbb43597d2bb2023-11-23T08:27:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239514310.3390/ijms23095143Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from FoodCarmen Ranftler0Andreas Röhrich1Andreas Sparer2Cornelius Tschegg3Dietmar Nagl4Glock Health, Science and Research GmbH, Hausfeldstraße 17, 2232 Deutsch-Wagram, AustriaGlock Health, Science and Research GmbH, Hausfeldstraße 17, 2232 Deutsch-Wagram, AustriaGlock Health, Science and Research GmbH, Hausfeldstraße 17, 2232 Deutsch-Wagram, AustriaGlock Health, Science and Research GmbH, Hausfeldstraße 17, 2232 Deutsch-Wagram, AustriaGlock Health, Science and Research GmbH, Hausfeldstraße 17, 2232 Deutsch-Wagram, AustriaVarious gluten-related diseases (celiac disease, wheat allergy, gluten sensitivity) are known and their incidence is growing. Gluten is a specific type of plant storage protein that can impair the health of gluten-prone persons following consumption, depending on the origin. The most severe effects are induced by wheat, barley, and rye. The only treatment is based on the absolute avoidance of those foods, as even traces might have severe effects on human well-being. With the goal of binding gluten impurities after ingestion, an in vitro setting was created. A special processed kind of zeolite, purified clinoptilolite-tuff (PCT), was implemented as an adsorber of gluten derived from different origins. Zeolites are known for their excellent sorption capacities and their applications in humans and animals have been studied for a long time. Tests were also performed in artificial gastric and intestinal fluids, and the adsorption capacity was determined via a certified validated method (ELISA). Depending on the kind of gluten source, 80–130 µg/mg of gluten were bound onto PCT. Hence, purified clinoptilolite-tuff, which was successfully tested for wheat, barley, and rye, proved to be suitable for the adsorption of gluten originating from different kinds of crops. This result might form the basis for an expedient human study in the future.https://www.mdpi.com/1422-0067/23/9/5143zeoliteceliac diseaseprolaminglutengliadinwheat allergy |
| spellingShingle | Carmen Ranftler Andreas Röhrich Andreas Sparer Cornelius Tschegg Dietmar Nagl Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food International Journal of Molecular Sciences zeolite celiac disease prolamin gluten gliadin wheat allergy |
| title | Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food |
| title_full | Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food |
| title_fullStr | Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food |
| title_full_unstemmed | Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food |
| title_short | Purified Clinoptilolite-Tuff as an Efficient Sorbent for Gluten Derived from Food |
| title_sort | purified clinoptilolite tuff as an efficient sorbent for gluten derived from food |
| topic | zeolite celiac disease prolamin gluten gliadin wheat allergy |
| url | https://www.mdpi.com/1422-0067/23/9/5143 |
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