Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications
Coordination complexes (<b>1</b>–<b>4</b>) of 2-amino-4-methylbenzothiazole and 2-amino-3-methylpyridine with Cu(CH<sub>3</sub>COO)<sub>2</sub> and AgNO<sub>3</sub> were prepared and characterized by UV/Vis and FT-IR spectroscopy. The molec...
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MDPI AG
2023-04-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/4/152 |
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| author | Muhammad Hanif Awal Noor Mian Muhammad Farhat Ullah Muhammad Nawaz Tahir Gul Shahzada Khan Ezzat Khan |
| author_facet | Muhammad Hanif Awal Noor Mian Muhammad Farhat Ullah Muhammad Nawaz Tahir Gul Shahzada Khan Ezzat Khan |
| author_sort | Muhammad Hanif |
| collection | DOAJ |
| description | Coordination complexes (<b>1</b>–<b>4</b>) of 2-amino-4-methylbenzothiazole and 2-amino-3-methylpyridine with Cu(CH<sub>3</sub>COO)<sub>2</sub> and AgNO<sub>3</sub> were prepared and characterized by UV/Vis and FT-IR spectroscopy. The molecular structure for single crystals of silver complexes (<b>2</b> and <b>4</b>) were determined by X-ray diffraction. The coordination complex (<b>2</b>) is monoclinic with space group <i>P</i>21/c, wherein two ligands are coordinated to a metal ion, affording distorted trigonal geometry around the central Ag metal ion. The efficient nucleophilic center, i.e., the endocyclic nitrogen of the organic ligand, binds to the silver metal. Ligands are coordinated to adopt <i>cis</i> arrangement, predominantly due to steric reasons. The O(2) and O(3) atoms of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>N</mi><msubsup><mi>O</mi><mn>3</mn><mo>−</mo></msubsup></mrow></semantics></math></inline-formula> group further play an important role in such type of ligand arrangement by hydrogen bonding with the NH<sub>2</sub> group of ligands. Complex (<b>4</b>) is orthorhombic, <i>P</i>212121, comprising two molecules of 2-amino-3-methylpyridine as ligand coordinated with the metal ion, affording a polymeric structure. The coordination behavior of the ligand is identical to that in complex <b>2</b>, wherein ring nitrogen is coordinated to the metal center and bridged to another metal ion through an NH<sub>2</sub> group. The resulting product is polymeric in nature with the Ag metal in the backbone and ligand as the bridge. Compounds (<b>2</b>–<b>4</b>) were found to be luminescent, while <b>1</b> did not show such activity. All compounds were screened for their preliminary biological activities such as antibacterial, antioxidant and enzyme inhibition. Compounds exhibited moderate activity in these tests. |
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| id | doaj.art-63311c7a1dc346f3a40031806517704e |
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| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-11T04:55:07Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-63311c7a1dc346f3a40031806517704e2023-11-17T19:45:20ZengMDPI AGInorganics2304-67402023-04-0111415210.3390/inorganics11040152Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological ApplicationsMuhammad Hanif0Awal Noor1Mian Muhammad2Farhat Ullah3Muhammad Nawaz Tahir4Gul Shahzada Khan5Ezzat Khan6Department of Chemistry, University of Malakand, Chakdara 18800, Khyber Pakhtunkhwa, PakistanDepartment of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Hassa 31982, Saudi ArabiaDepartment of Chemistry, University of Malakand, Chakdara 18800, Khyber Pakhtunkhwa, PakistanDepartment of Pharmacy, University of Malakand, Chakdara 18800, Khyber Pakhtunkhwa, PakistanDepartment of Physics, University of Sargodha, Sargodha 40100, Punjab, PakistanDepartment of Chemistry, College of Science, University of Bahrain, Main Campus, Sakhir 32038, BahrainDepartment of Chemistry, University of Malakand, Chakdara 18800, Khyber Pakhtunkhwa, PakistanCoordination complexes (<b>1</b>–<b>4</b>) of 2-amino-4-methylbenzothiazole and 2-amino-3-methylpyridine with Cu(CH<sub>3</sub>COO)<sub>2</sub> and AgNO<sub>3</sub> were prepared and characterized by UV/Vis and FT-IR spectroscopy. The molecular structure for single crystals of silver complexes (<b>2</b> and <b>4</b>) were determined by X-ray diffraction. The coordination complex (<b>2</b>) is monoclinic with space group <i>P</i>21/c, wherein two ligands are coordinated to a metal ion, affording distorted trigonal geometry around the central Ag metal ion. The efficient nucleophilic center, i.e., the endocyclic nitrogen of the organic ligand, binds to the silver metal. Ligands are coordinated to adopt <i>cis</i> arrangement, predominantly due to steric reasons. The O(2) and O(3) atoms of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>N</mi><msubsup><mi>O</mi><mn>3</mn><mo>−</mo></msubsup></mrow></semantics></math></inline-formula> group further play an important role in such type of ligand arrangement by hydrogen bonding with the NH<sub>2</sub> group of ligands. Complex (<b>4</b>) is orthorhombic, <i>P</i>212121, comprising two molecules of 2-amino-3-methylpyridine as ligand coordinated with the metal ion, affording a polymeric structure. The coordination behavior of the ligand is identical to that in complex <b>2</b>, wherein ring nitrogen is coordinated to the metal center and bridged to another metal ion through an NH<sub>2</sub> group. The resulting product is polymeric in nature with the Ag metal in the backbone and ligand as the bridge. Compounds (<b>2</b>–<b>4</b>) were found to be luminescent, while <b>1</b> did not show such activity. All compounds were screened for their preliminary biological activities such as antibacterial, antioxidant and enzyme inhibition. Compounds exhibited moderate activity in these tests.https://www.mdpi.com/2304-6740/11/4/1522-amino-3-methylpyridine2-amino-4-methylbenzothiazolecopper complexessilver complexescoordination polymersbiological applications |
| spellingShingle | Muhammad Hanif Awal Noor Mian Muhammad Farhat Ullah Muhammad Nawaz Tahir Gul Shahzada Khan Ezzat Khan Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications Inorganics 2-amino-3-methylpyridine 2-amino-4-methylbenzothiazole copper complexes silver complexes coordination polymers biological applications |
| title | Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications |
| title_full | Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications |
| title_fullStr | Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications |
| title_full_unstemmed | Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications |
| title_short | Complexes of 2-Amino-3-methylpyridine and 2-Amino-4-methylbenzothiazole with Ag(I) and Cu(II): Structure and Biological Applications |
| title_sort | complexes of 2 amino 3 methylpyridine and 2 amino 4 methylbenzothiazole with ag i and cu ii structure and biological applications |
| topic | 2-amino-3-methylpyridine 2-amino-4-methylbenzothiazole copper complexes silver complexes coordination polymers biological applications |
| url | https://www.mdpi.com/2304-6740/11/4/152 |
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