Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
Emerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Environmental Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fenvs.2022.963537/full |
| _version_ | 1817999549842587648 |
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| author | Eduardo Feijão Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Irina A. Duarte Ana Rita Matos Ana Rita Matos Maria Teresa Cabrita Maria Teresa Cabrita Andrei B. Utkin Andrei B. Utkin Isabel Caçador Isabel Caçador João Carlos Marques Sara C. Novais Marco F. L. Lemos Patrick Reis-Santos Patrick Reis-Santos Vanessa F. Fonseca Vanessa F. Fonseca Bernardo Duarte Bernardo Duarte |
| author_facet | Eduardo Feijão Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Irina A. Duarte Ana Rita Matos Ana Rita Matos Maria Teresa Cabrita Maria Teresa Cabrita Andrei B. Utkin Andrei B. Utkin Isabel Caçador Isabel Caçador João Carlos Marques Sara C. Novais Marco F. L. Lemos Patrick Reis-Santos Patrick Reis-Santos Vanessa F. Fonseca Vanessa F. Fonseca Bernardo Duarte Bernardo Duarte |
| author_sort | Eduardo Feijão |
| collection | DOAJ |
| description | Emerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1. The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies. |
| first_indexed | 2024-04-14T03:10:24Z |
| format | Article |
| id | doaj.art-63312f8217894db39ee37d1e150d0de2 |
| institution | Directory Open Access Journal |
| issn | 2296-665X |
| language | English |
| last_indexed | 2024-04-14T03:10:24Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Environmental Science |
| spelling | doaj.art-63312f8217894db39ee37d1e150d0de22022-12-22T02:15:36ZengFrontiers Media S.A.Frontiers in Environmental Science2296-665X2022-08-011010.3389/fenvs.2022.963537963537Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactucaEduardo Feijão0Ricardo Cruz de Carvalho1Ricardo Cruz de Carvalho2Ricardo Cruz de Carvalho3Irina A. Duarte4Ana Rita Matos5Ana Rita Matos6Maria Teresa Cabrita7Maria Teresa Cabrita8Andrei B. Utkin9Andrei B. Utkin10Isabel Caçador11Isabel Caçador12João Carlos Marques13Sara C. Novais14Marco F. L. Lemos15Patrick Reis-Santos16Patrick Reis-Santos17Vanessa F. Fonseca18Vanessa F. Fonseca19Bernardo Duarte20Bernardo Duarte21MARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, PortugalcE3c, Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalDepartamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, PortugalDepartamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalBioISI - Biosystems and Integrative Sciences Institute, Plant Functional Genomics Group, Departamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalCentro de Estudos Geográficos, Instituto de Geografia e Ordenamento do Território, Universidade de Lisboa, Lisboa, PortugalLaboratório Associado Terra, Lisboa, PortugalINOV-INESC, Lisboa, PortugalCeFEMA, Universidade de Lisboa, Lisboa, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, PortugalDepartamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory c/o Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal0MARE – Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, ESTM, Politécnico de Leiria, Peniche, Portugal0MARE – Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, ESTM, Politécnico de Leiria, Peniche, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal1Southern Seas Ecology Laboratories, School of Biological Sciences, The University of Adelaide, Adelaide, SA, AustraliaMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal2Departamento de Biologia Animal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalMARE - Marine and Environmental Sciences Centre and ARNET – Aquatic Research Infrastructure Network Associate Laboratory, Faculdade de Ciências da Universidade de Lisboa, Lisbon, PortugalDepartamento de Biologia Vegetal, Faculdade de Ciências da Universidade de Lisboa, Lisboa, PortugalEmerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1. The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies.https://www.frontiersin.org/articles/10.3389/fenvs.2022.963537/fullantidepressantsmacroalgaeoxidative stresspharmaceuticalsphotobiology |
| spellingShingle | Eduardo Feijão Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Ricardo Cruz de Carvalho Irina A. Duarte Ana Rita Matos Ana Rita Matos Maria Teresa Cabrita Maria Teresa Cabrita Andrei B. Utkin Andrei B. Utkin Isabel Caçador Isabel Caçador João Carlos Marques Sara C. Novais Marco F. L. Lemos Patrick Reis-Santos Patrick Reis-Santos Vanessa F. Fonseca Vanessa F. Fonseca Bernardo Duarte Bernardo Duarte Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca Frontiers in Environmental Science antidepressants macroalgae oxidative stress pharmaceuticals photobiology |
| title | Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
| title_full | Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
| title_fullStr | Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
| title_full_unstemmed | Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
| title_short | Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca |
| title_sort | fluoxetine induces photochemistry derived oxidative stress on ulva lactuca |
| topic | antidepressants macroalgae oxidative stress pharmaceuticals photobiology |
| url | https://www.frontiersin.org/articles/10.3389/fenvs.2022.963537/full |
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