Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity
Abstract Background Among adult malignant tumors, renal cell carcinoma accounts for 2–3% and has the worst prognosis among common urologic tumors. Recently, an eosinophilic, solid and cystic (ESC) renal cell carcinoma (RCC) histological subtype has been described and proposed as an entity separate t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | African Journal of Urology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12301-022-00312-8 |
| _version_ | 1811265124758978560 |
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| author | Niramya Jagdish Pathak Abhishek Gajendra Singh Pavan Surwase Jain Shailesh Mahendra Soni Arvind Prakash Ganpule Ravindra Bhalchandra Sabnis Mahesh Ramanlal Desai |
| author_facet | Niramya Jagdish Pathak Abhishek Gajendra Singh Pavan Surwase Jain Shailesh Mahendra Soni Arvind Prakash Ganpule Ravindra Bhalchandra Sabnis Mahesh Ramanlal Desai |
| author_sort | Niramya Jagdish Pathak |
| collection | DOAJ |
| description | Abstract Background Among adult malignant tumors, renal cell carcinoma accounts for 2–3% and has the worst prognosis among common urologic tumors. Recently, an eosinophilic, solid and cystic (ESC) renal cell carcinoma (RCC) histological subtype has been described and proposed as an entity separate than the 16 subtypes described in the 2016 WHO classification. The aim of the present study is to share our experience of three such cases of this newly described entity. Methods We retrospectively reviewed our cases of renal cell carcinoma and describe the presentation, diagnosis and management with follow-up details of ESC RCC. Results Our three patients presented at an advanced stage with flank pain or mass, and one patient had metastasis. All patients underwent radical nephrectomy, diagnosis proved by histopathological examination with immunohistochemistry (IHC), with abundant eosinophilic cytoplasm in all three cases. On IHC, CK 20 was positive in two cases and one patient with CK 20, CK 7 negative and PAX 8 positive. Conclusions ESC RCC is a newly described entity, with increasing incidence probably due to better diagnosis. Previously, 66 such cases are described, with female predominance, lower stage and indolent behavior. Only four cases with metastasis are described. |
| first_indexed | 2024-04-12T20:17:10Z |
| format | Article |
| id | doaj.art-6333afce7c8942d4880289f1c5d4b28c |
| institution | Directory Open Access Journal |
| issn | 1110-5704 1961-9987 |
| language | English |
| last_indexed | 2024-04-12T20:17:10Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-6333afce7c8942d4880289f1c5d4b28c2022-12-22T03:18:05ZengSpringerOpenAfrican Journal of Urology1110-57041961-99872022-09-012811710.1186/s12301-022-00312-8Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entityNiramya Jagdish Pathak0Abhishek Gajendra Singh1Pavan Surwase Jain2Shailesh Mahendra Soni3Arvind Prakash Ganpule4Ravindra Bhalchandra Sabnis5Mahesh Ramanlal Desai6MPUHMPUHMPUHMPUHMPUHMPUHMPUHAbstract Background Among adult malignant tumors, renal cell carcinoma accounts for 2–3% and has the worst prognosis among common urologic tumors. Recently, an eosinophilic, solid and cystic (ESC) renal cell carcinoma (RCC) histological subtype has been described and proposed as an entity separate than the 16 subtypes described in the 2016 WHO classification. The aim of the present study is to share our experience of three such cases of this newly described entity. Methods We retrospectively reviewed our cases of renal cell carcinoma and describe the presentation, diagnosis and management with follow-up details of ESC RCC. Results Our three patients presented at an advanced stage with flank pain or mass, and one patient had metastasis. All patients underwent radical nephrectomy, diagnosis proved by histopathological examination with immunohistochemistry (IHC), with abundant eosinophilic cytoplasm in all three cases. On IHC, CK 20 was positive in two cases and one patient with CK 20, CK 7 negative and PAX 8 positive. Conclusions ESC RCC is a newly described entity, with increasing incidence probably due to better diagnosis. Previously, 66 such cases are described, with female predominance, lower stage and indolent behavior. Only four cases with metastasis are described.https://doi.org/10.1186/s12301-022-00312-8ESCRCCEosinophilic solid cysticRenal cell cancer |
| spellingShingle | Niramya Jagdish Pathak Abhishek Gajendra Singh Pavan Surwase Jain Shailesh Mahendra Soni Arvind Prakash Ganpule Ravindra Bhalchandra Sabnis Mahesh Ramanlal Desai Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity African Journal of Urology ESC RCC Eosinophilic solid cystic Renal cell cancer |
| title | Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity |
| title_full | Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity |
| title_fullStr | Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity |
| title_full_unstemmed | Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity |
| title_short | Eosinophilic solid and cystic renal cell carcinoma: a single Indian tertiary center experience of three cases of a newly described entity |
| title_sort | eosinophilic solid and cystic renal cell carcinoma a single indian tertiary center experience of three cases of a newly described entity |
| topic | ESC RCC Eosinophilic solid cystic Renal cell cancer |
| url | https://doi.org/10.1186/s12301-022-00312-8 |
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