Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study
Abstract Background Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease. However, little attention has been given to the association between TyG-BMI and cardiovascular disease (CVD) mortality in pati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01892-2 |
| _version_ | 1797451686217777152 |
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| author | Cuixia Zhan Yuan Peng Hongjian Ye Xiangwen Diao Chunyan Yi Qunying Guo Wei Chen Xiao Yang |
| author_facet | Cuixia Zhan Yuan Peng Hongjian Ye Xiangwen Diao Chunyan Yi Qunying Guo Wei Chen Xiao Yang |
| author_sort | Cuixia Zhan |
| collection | DOAJ |
| description | Abstract Background Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease. However, little attention has been given to the association between TyG-BMI and cardiovascular disease (CVD) mortality in patients undergoing peritoneal dialysis (PD). Therefore, this study aimed to explore the relationship between TyG-BMI and CVD mortality in southern Chinese patients undergoing PD. Methods Incident patients receiving PD from January 1, 2006, to December 31, 2018, with baseline serum triglyceride, glucose, and body mass index (BMI) information, were recruited for this single-center retrospective cohort study. TyG-BMI was calculated based on fasting plasma glucose, triglyceride, and BMI values. The association between TyG-BMI, CVD and all-cause mortality was evaluated using a multivariate-adjusted Cox proportional hazard regression model. Results Of 2,335 patients, the mean age was 46.1 ± 14.8 years; 1,382 (59.2%) were male, and 564 (24.2%) had diabetes. The median TyG-BMI was 183.7 (165.5–209.2). Multivariate linear regression showed that advanced age, male sex, history of CVD, higher levels of albumin and low-density lipoprotein cholesterol, and higher urine output were correlated with a higher TyG-BMI (P < 0.05). During a median follow-up period of 46.6 (22.4–78.0) months, 615 patients died, of whom 297 (48.2%) died as a result of CVD. After adjusting for demographics and comorbidities, TyG-BMI was significantly associated with an increased risk of CVD mortality (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.05–2.17) and all-cause mortality (HR 1.36, 95% CI 1.05–1.75). After full adjustment, the 28% risk of CVD mortality (HR 1.28, 95% CI 1.13–1.45) and 19% risk of all-cause mortality were elevated (HR 1.19, 95% CI 1.09–1.31) when TyG-BMI increased by 1 stand deviation (SD) (34.2). Conclusions A higher baseline TyG-BMI was independently associated with an increased risk of CVD and all-cause mortality in patients receiving PD. |
| first_indexed | 2024-03-09T14:58:06Z |
| format | Article |
| id | doaj.art-6334162ed39441e6a212b553e7ce58a3 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-09T14:58:06Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-6334162ed39441e6a212b553e7ce58a32023-11-26T14:05:40ZengBMCLipids in Health and Disease1476-511X2023-09-012211910.1186/s12944-023-01892-2Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort studyCuixia Zhan0Yuan Peng1Hongjian Ye2Xiangwen Diao3Chunyan Yi4Qunying Guo5Wei Chen6Xiao Yang7Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease. However, little attention has been given to the association between TyG-BMI and cardiovascular disease (CVD) mortality in patients undergoing peritoneal dialysis (PD). Therefore, this study aimed to explore the relationship between TyG-BMI and CVD mortality in southern Chinese patients undergoing PD. Methods Incident patients receiving PD from January 1, 2006, to December 31, 2018, with baseline serum triglyceride, glucose, and body mass index (BMI) information, were recruited for this single-center retrospective cohort study. TyG-BMI was calculated based on fasting plasma glucose, triglyceride, and BMI values. The association between TyG-BMI, CVD and all-cause mortality was evaluated using a multivariate-adjusted Cox proportional hazard regression model. Results Of 2,335 patients, the mean age was 46.1 ± 14.8 years; 1,382 (59.2%) were male, and 564 (24.2%) had diabetes. The median TyG-BMI was 183.7 (165.5–209.2). Multivariate linear regression showed that advanced age, male sex, history of CVD, higher levels of albumin and low-density lipoprotein cholesterol, and higher urine output were correlated with a higher TyG-BMI (P < 0.05). During a median follow-up period of 46.6 (22.4–78.0) months, 615 patients died, of whom 297 (48.2%) died as a result of CVD. After adjusting for demographics and comorbidities, TyG-BMI was significantly associated with an increased risk of CVD mortality (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.05–2.17) and all-cause mortality (HR 1.36, 95% CI 1.05–1.75). After full adjustment, the 28% risk of CVD mortality (HR 1.28, 95% CI 1.13–1.45) and 19% risk of all-cause mortality were elevated (HR 1.19, 95% CI 1.09–1.31) when TyG-BMI increased by 1 stand deviation (SD) (34.2). Conclusions A higher baseline TyG-BMI was independently associated with an increased risk of CVD and all-cause mortality in patients receiving PD.https://doi.org/10.1186/s12944-023-01892-2TyG-BMICardiovascular mortalityPeritoneal dialysis |
| spellingShingle | Cuixia Zhan Yuan Peng Hongjian Ye Xiangwen Diao Chunyan Yi Qunying Guo Wei Chen Xiao Yang Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study Lipids in Health and Disease TyG-BMI Cardiovascular mortality Peritoneal dialysis |
| title | Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study |
| title_full | Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study |
| title_fullStr | Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study |
| title_full_unstemmed | Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study |
| title_short | Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study |
| title_sort | triglyceride glucose body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis a retrospective cohort study |
| topic | TyG-BMI Cardiovascular mortality Peritoneal dialysis |
| url | https://doi.org/10.1186/s12944-023-01892-2 |
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