Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.

Bibliographic Details
Main Authors: Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Kevin Cao, Richard H. Kramer, Dirk Trauner, John Flannery, Ehud Y. Isacoff
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01990-7

Internet

https://doi.org/10.1038/s41467-017-01990-7

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