The effect of celecoxib on orthodontic tooth movement and root resorption in rat.
Inhibition of prostaglandin (PGs) production leads to decrease in orthodontic tooth movement (OTM). It is not known whether inhibition of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) is the key mechanism for this effect. In this study, the effect of celecoxib, a highly-selective COX-2 inhibi...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-07-01
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| Series: | Frontiers in Dentistry |
| Subjects: | |
| Online Access: | https://jdt.tums.ac.ir/index.php/jdt/article/view/642 |
| _version_ | 1818350978283339776 |
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| author | Ahmad Sodagar Tahura Etezadi Pouria Motahhary Ahmad Reza Dehpour Hamed Vaziri Arash Khojasteh |
| author_facet | Ahmad Sodagar Tahura Etezadi Pouria Motahhary Ahmad Reza Dehpour Hamed Vaziri Arash Khojasteh |
| author_sort | Ahmad Sodagar |
| collection | DOAJ |
| description | Inhibition of prostaglandin (PGs) production leads to decrease in orthodontic tooth movement (OTM). It is not known whether inhibition of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) is the key mechanism for this effect. In this study, the effect of celecoxib, a highly-selective COX-2 inhibitor, was investigated on OTM in rats.Four groups of male rats (seven animals in each goup) were used in the study. A 5mm-long nickel-titanium closed-coil spring was ligated between the right maxillary incisor and the first molar of each rat to deliver an initial force of 60g. All four groups recieved orthodontic appliances, group 1 received no injections, group 2 received celecoxib injections (0.3 mg in 0.1 ml saline solution), group 3 recieved normal saline injections (0.1 ml saline solution), and group 4 recieved needle penetration without injecting any solution. The local injections were carried out every 3 days for 18 days. All injections were subperiosteal and given in the upper right first molar mucosa. The animals were sacrificed 21 days after appliance insertion and OTM was measured.In the animals treated with celecoxib a statistically significant decrease in OTM was observed compared with the other groups. Histological findings revealed that osteoclast count was significantly lower in group 2 compared with the other groups (P |
| first_indexed | 2024-12-13T18:30:26Z |
| format | Article |
| id | doaj.art-6338fba665da472fbbd1939d45956b80 |
| institution | Directory Open Access Journal |
| issn | 2676-296X |
| language | English |
| last_indexed | 2024-12-13T18:30:26Z |
| publishDate | 2013-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Dentistry |
| spelling | doaj.art-6338fba665da472fbbd1939d45956b802022-12-21T23:35:29ZengTehran University of Medical SciencesFrontiers in Dentistry2676-296X2013-07-01104The effect of celecoxib on orthodontic tooth movement and root resorption in rat.Ahmad Sodagar0Tahura Etezadi1Pouria Motahhary2Ahmad Reza Dehpour3Hamed Vaziri4Arash Khojasteh5Associate Professor, Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Resident of Orthodontics, Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Associate Professor, Department of Oral Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.Professor Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Orthodontist, Private Practice, Farmington CT, USA.Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Director of Basic Science research, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Inhibition of prostaglandin (PGs) production leads to decrease in orthodontic tooth movement (OTM). It is not known whether inhibition of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) is the key mechanism for this effect. In this study, the effect of celecoxib, a highly-selective COX-2 inhibitor, was investigated on OTM in rats.Four groups of male rats (seven animals in each goup) were used in the study. A 5mm-long nickel-titanium closed-coil spring was ligated between the right maxillary incisor and the first molar of each rat to deliver an initial force of 60g. All four groups recieved orthodontic appliances, group 1 received no injections, group 2 received celecoxib injections (0.3 mg in 0.1 ml saline solution), group 3 recieved normal saline injections (0.1 ml saline solution), and group 4 recieved needle penetration without injecting any solution. The local injections were carried out every 3 days for 18 days. All injections were subperiosteal and given in the upper right first molar mucosa. The animals were sacrificed 21 days after appliance insertion and OTM was measured.In the animals treated with celecoxib a statistically significant decrease in OTM was observed compared with the other groups. Histological findings revealed that osteoclast count was significantly lower in group 2 compared with the other groups (Phttps://jdt.tums.ac.ir/index.php/jdt/article/view/642CelecoxibCyclooxygenaseOrthodonticsProstaglandinsRatsTooth Movement |
| spellingShingle | Ahmad Sodagar Tahura Etezadi Pouria Motahhary Ahmad Reza Dehpour Hamed Vaziri Arash Khojasteh The effect of celecoxib on orthodontic tooth movement and root resorption in rat. Frontiers in Dentistry Celecoxib Cyclooxygenase Orthodontics Prostaglandins Rats Tooth Movement |
| title | The effect of celecoxib on orthodontic tooth movement and root resorption in rat. |
| title_full | The effect of celecoxib on orthodontic tooth movement and root resorption in rat. |
| title_fullStr | The effect of celecoxib on orthodontic tooth movement and root resorption in rat. |
| title_full_unstemmed | The effect of celecoxib on orthodontic tooth movement and root resorption in rat. |
| title_short | The effect of celecoxib on orthodontic tooth movement and root resorption in rat. |
| title_sort | effect of celecoxib on orthodontic tooth movement and root resorption in rat |
| topic | Celecoxib Cyclooxygenase Orthodontics Prostaglandins Rats Tooth Movement |
| url | https://jdt.tums.ac.ir/index.php/jdt/article/view/642 |
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