Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease

Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton’s tyrosine kinase...

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Bibliographic Details
Main Authors: Fani Ziouti, Maximilian Rummler, Beatrice Steyn, Tobias Thiele, Anne Seliger, Georg N. Duda, Bjarne Bogen, Bettina M. Willie, Franziska Jundt
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
multiple myeloma
cancer-induced bone disease
Bruton’s tyrosine kinase inhibitor CC-292
skeletal mechanobiology
bone adaptation
mechanical loading
Online Access:https://www.mdpi.com/1422-0067/22/8/3840

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