Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2
Objectives: We assessed the effect of inactivated COVID-19 vaccine boosting immunization on the viral shedding time for patients infected with the Omicron variant BA.2. Methods: We performed a real-world study by analyzing the outbreak data of patients infected with the COVID-19 Omicron variant BA.2...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223001078 |
| _version_ | 1827971450770817024 |
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| author | Jun Wu Xinling Shi Bilin Tao Yiyang Zhan Xiang Lu Jianming Wang |
| author_facet | Jun Wu Xinling Shi Bilin Tao Yiyang Zhan Xiang Lu Jianming Wang |
| author_sort | Jun Wu |
| collection | DOAJ |
| description | Objectives: We assessed the effect of inactivated COVID-19 vaccine boosting immunization on the viral shedding time for patients infected with the Omicron variant BA.2. Methods: We performed a real-world study by analyzing the outbreak data of patients infected with the COVID-19 Omicron variant BA.2 from March to May 2022 in Shanghai, China. Patients were categorized into three groups, including not fully vaccinated (zero and one dose), fully vaccinated (two doses), and booster-vaccinated (three doses). Results: A total of 4443 patients infected with COVID-19 were included in the analysis. The proportion of viral shedding within 14 days in the three groups was 94.7%, 95.5%, and 96.7%, respectively (P <0.001). After adjusting for sex, age, underlying conditions, and clinical symptoms, the booster vaccination had a 29% increased possibility (hazard ratio: 1.29, 95% confidence interval: 1.18-1.41) of no detectable viral shedding within 14 days, whereas the fully vaccinated group had an 11% increased possibility of no detectable viral shedding (hazard ratio: 1.11, 95% confidence interval: 1.01-1.23). The effect of booster vaccination was more significant in males, the elderly, and people with underlying conditions or symptomatic infections. Conclusion: Our study confirmed that the booster vaccination could significantly shorten the viral shedding time of patients infected with the Omicron variant BA.2. |
| first_indexed | 2024-04-09T19:09:10Z |
| format | Article |
| id | doaj.art-633aaf9560ba4e8eb5c42cf5815ff2f0 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T19:09:10Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-633aaf9560ba4e8eb5c42cf5815ff2f02023-04-07T06:48:34ZengElsevierInternational Journal of Infectious Diseases1201-97122023-06-011312631Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2Jun Wu0Xinling Shi1Bilin Tao2Yiyang Zhan3Xiang Lu4Jianming Wang5Department of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, Gusu School, Nanjing Medical University, Nanjing, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, Gusu School, Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China; Corresponding author: Tel: 86-25- 68305277Department of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China; Corresponding author: Tel: 86-25-87115509Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Epidemiology, Gusu School, Nanjing Medical University, Nanjing, China; Corresponding author: Tel: 86-25-86868414Objectives: We assessed the effect of inactivated COVID-19 vaccine boosting immunization on the viral shedding time for patients infected with the Omicron variant BA.2. Methods: We performed a real-world study by analyzing the outbreak data of patients infected with the COVID-19 Omicron variant BA.2 from March to May 2022 in Shanghai, China. Patients were categorized into three groups, including not fully vaccinated (zero and one dose), fully vaccinated (two doses), and booster-vaccinated (three doses). Results: A total of 4443 patients infected with COVID-19 were included in the analysis. The proportion of viral shedding within 14 days in the three groups was 94.7%, 95.5%, and 96.7%, respectively (P <0.001). After adjusting for sex, age, underlying conditions, and clinical symptoms, the booster vaccination had a 29% increased possibility (hazard ratio: 1.29, 95% confidence interval: 1.18-1.41) of no detectable viral shedding within 14 days, whereas the fully vaccinated group had an 11% increased possibility of no detectable viral shedding (hazard ratio: 1.11, 95% confidence interval: 1.01-1.23). The effect of booster vaccination was more significant in males, the elderly, and people with underlying conditions or symptomatic infections. Conclusion: Our study confirmed that the booster vaccination could significantly shorten the viral shedding time of patients infected with the Omicron variant BA.2.http://www.sciencedirect.com/science/article/pii/S1201971223001078COVID-19Inactivated vaccineBooster doseViral shedding timeOmicron variant |
| spellingShingle | Jun Wu Xinling Shi Bilin Tao Yiyang Zhan Xiang Lu Jianming Wang Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 International Journal of Infectious Diseases COVID-19 Inactivated vaccine Booster dose Viral shedding time Omicron variant |
| title | Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 |
| title_full | Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 |
| title_fullStr | Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 |
| title_full_unstemmed | Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 |
| title_short | Inactivated COVID-19 vaccine booster dose shortened the viral shedding time of patients infected with the Omicron variant BA.2 |
| title_sort | inactivated covid 19 vaccine booster dose shortened the viral shedding time of patients infected with the omicron variant ba 2 |
| topic | COVID-19 Inactivated vaccine Booster dose Viral shedding time Omicron variant |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223001078 |
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