Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure
In the budding yeast <i>Saccharomyces cerevisiae</i>, sporulation occurs during starvation of a diploid cell and results in the formation of four haploid spores forming within the mother cell ascus. Meiosis divides the genetic material that is encapsulated by the prospore membrane that g...
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MDPI AG
2024-02-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/10/2/132 |
| _version_ | 1797297739023777792 |
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| author | Matthew Durant Xheni Mucelli Linda S. Huang |
| author_facet | Matthew Durant Xheni Mucelli Linda S. Huang |
| author_sort | Matthew Durant |
| collection | DOAJ |
| description | In the budding yeast <i>Saccharomyces cerevisiae</i>, sporulation occurs during starvation of a diploid cell and results in the formation of four haploid spores forming within the mother cell ascus. Meiosis divides the genetic material that is encapsulated by the prospore membrane that grows to surround the haploid nuclei; this membrane will eventually become the plasma membrane of the haploid spore. Cellularization of the spores occurs when the prospore membrane closes to capture the haploid nucleus along with some cytoplasmic material from the mother cell, and thus, closure of the prospore membrane is the meiotic cytokinetic event. This cytokinetic event involves the removal of the leading-edge protein complex, a complex of proteins that localizes to the leading edge of the growing prospore membrane. The development and closure of the prospore membrane must be coordinated with other meiotic exit events such as spindle disassembly. Timing of the closure of the prospore membrane depends on the meiotic exit pathway, which utilizes Cdc15, a Hippo-like kinase, and Sps1, an STE20 family GCKIII kinase, acting in parallel to the E3 ligase Ama1-APC/C. This review describes the sporulation process and focuses on the development of the prospore membrane and the regulation of prospore membrane closure. |
| first_indexed | 2024-03-07T22:25:40Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-07T22:25:40Z |
| publishDate | 2024-02-01 |
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| series | Journal of Fungi |
| spelling | doaj.art-633bdfe63cc1423e899f18ce263c00632024-02-23T15:23:31ZengMDPI AGJournal of Fungi2309-608X2024-02-0110213210.3390/jof10020132Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need ClosureMatthew Durant0Xheni Mucelli1Linda S. Huang2Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USADepartment of Biology, University of Massachusetts Boston, Boston, MA 02125, USADepartment of Biology, University of Massachusetts Boston, Boston, MA 02125, USAIn the budding yeast <i>Saccharomyces cerevisiae</i>, sporulation occurs during starvation of a diploid cell and results in the formation of four haploid spores forming within the mother cell ascus. Meiosis divides the genetic material that is encapsulated by the prospore membrane that grows to surround the haploid nuclei; this membrane will eventually become the plasma membrane of the haploid spore. Cellularization of the spores occurs when the prospore membrane closes to capture the haploid nucleus along with some cytoplasmic material from the mother cell, and thus, closure of the prospore membrane is the meiotic cytokinetic event. This cytokinetic event involves the removal of the leading-edge protein complex, a complex of proteins that localizes to the leading edge of the growing prospore membrane. The development and closure of the prospore membrane must be coordinated with other meiotic exit events such as spindle disassembly. Timing of the closure of the prospore membrane depends on the meiotic exit pathway, which utilizes Cdc15, a Hippo-like kinase, and Sps1, an STE20 family GCKIII kinase, acting in parallel to the E3 ligase Ama1-APC/C. This review describes the sporulation process and focuses on the development of the prospore membrane and the regulation of prospore membrane closure.https://www.mdpi.com/2309-608X/10/2/132meiosiscell cyclebudding yeastprospore membranecellularizationmeiotic exit |
| spellingShingle | Matthew Durant Xheni Mucelli Linda S. Huang Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure Journal of Fungi meiosis cell cycle budding yeast prospore membrane cellularization meiotic exit |
| title | Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure |
| title_full | Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure |
| title_fullStr | Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure |
| title_full_unstemmed | Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure |
| title_short | Meiotic Cytokinesis in <i>Saccharomyces cerevisiae</i>: Spores That Just Need Closure |
| title_sort | meiotic cytokinesis in i saccharomyces cerevisiae i spores that just need closure |
| topic | meiosis cell cycle budding yeast prospore membrane cellularization meiotic exit |
| url | https://www.mdpi.com/2309-608X/10/2/132 |
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