Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial
Abstract Chronic low back pain (CLBP) is a disabling condition worldwide. In CLBP, neuroimaging studies demonstrate abnormal activities in cortical areas responsible for pain modulation, emotional, and sensory components of pain experience [i.e., pregenual and dorsal anterior cingulate cortex (pgACC...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28344-2 |
| _version_ | 1797945877126447104 |
|---|---|
| author | Divya Bharatkumar Adhia Ramakrishnan Mani Jerin Mathew Finella O’Leary Mark Smith Sven Vanneste Dirk De Ridder |
| author_facet | Divya Bharatkumar Adhia Ramakrishnan Mani Jerin Mathew Finella O’Leary Mark Smith Sven Vanneste Dirk De Ridder |
| author_sort | Divya Bharatkumar Adhia |
| collection | DOAJ |
| description | Abstract Chronic low back pain (CLBP) is a disabling condition worldwide. In CLBP, neuroimaging studies demonstrate abnormal activities in cortical areas responsible for pain modulation, emotional, and sensory components of pain experience [i.e., pregenual and dorsal anterior cingulate cortex (pgACC, dACC), and somatosensory cortex (SSC), respectively]. This pilot study, conducted in a university setting, evaluated the feasibility, safety, and acceptability of a novel electroencephalography-based infraslow-neurofeedback (EEG ISF-NF) technique for retraining activities in pgACC, dACC and SSC and explored its effects on pain and disability. Participants with CLBP (n = 60), recruited between July’20 to March’21, received 12 sessions of either: ISF-NF targeting pgACC, dACC + SSC, a ratio of pgACC*2/dACC + SSC, or Placebo-NF. Descriptive statistics demonstrated that ISF-NF training is feasible [recruitment rate (7 participants/month), dropouts (25%; 20–27%), and adherence (80%; 73–88%)], safe (no adverse events reported), and was moderate to highly acceptable [Mean ± SD: 7.8 ± 2.0 (pgACC), 7.5 ± 2.7 (dACC + SCC), 8.2 ± 1.9 (Ratio), and 7.7 ± 1.5 (Placebo)]. ISF-NF targeting pgACC demonstrated the most favourable clinical outcomes, with a higher proportion of participants exhibiting a clinically meaningful reduction in pain severity [53%; MD (95% CI): − 1.9 (− 2.7, − 1.0)], interference [80%; MD (95% CI): − 2.3 (− 3.5, − 1.2)], and disability [73%; MD (95% CI): − 4.5 (− 6.1, − 2.9)] at 1-month follow-up. ISF-NF training is a feasible, safe, and an acceptable treatment approach for CLBP. |
| first_indexed | 2024-04-10T21:02:05Z |
| format | Article |
| id | doaj.art-633d33833a3a41c3b17783a5620b8f76 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T21:02:05Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-633d33833a3a41c3b17783a5620b8f762023-01-22T12:14:27ZengNature PortfolioScientific Reports2045-23222023-01-0113111710.1038/s41598-023-28344-2Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trialDivya Bharatkumar Adhia0Ramakrishnan Mani1Jerin Mathew2Finella O’Leary3Mark Smith4Sven Vanneste5Dirk De Ridder6Department of Surgical Sciences, Otago Medical School, University of OtagoPain@Otago Research Theme, University of OtagoDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher EducationDepartment of Surgical Sciences, Otago Medical School, University of OtagoNeurofeedback Therapy Services of New YorkGlobal Brain Health Institute, Trinity College DublinDepartment of Surgical Sciences, Otago Medical School, University of OtagoAbstract Chronic low back pain (CLBP) is a disabling condition worldwide. In CLBP, neuroimaging studies demonstrate abnormal activities in cortical areas responsible for pain modulation, emotional, and sensory components of pain experience [i.e., pregenual and dorsal anterior cingulate cortex (pgACC, dACC), and somatosensory cortex (SSC), respectively]. This pilot study, conducted in a university setting, evaluated the feasibility, safety, and acceptability of a novel electroencephalography-based infraslow-neurofeedback (EEG ISF-NF) technique for retraining activities in pgACC, dACC and SSC and explored its effects on pain and disability. Participants with CLBP (n = 60), recruited between July’20 to March’21, received 12 sessions of either: ISF-NF targeting pgACC, dACC + SSC, a ratio of pgACC*2/dACC + SSC, or Placebo-NF. Descriptive statistics demonstrated that ISF-NF training is feasible [recruitment rate (7 participants/month), dropouts (25%; 20–27%), and adherence (80%; 73–88%)], safe (no adverse events reported), and was moderate to highly acceptable [Mean ± SD: 7.8 ± 2.0 (pgACC), 7.5 ± 2.7 (dACC + SCC), 8.2 ± 1.9 (Ratio), and 7.7 ± 1.5 (Placebo)]. ISF-NF targeting pgACC demonstrated the most favourable clinical outcomes, with a higher proportion of participants exhibiting a clinically meaningful reduction in pain severity [53%; MD (95% CI): − 1.9 (− 2.7, − 1.0)], interference [80%; MD (95% CI): − 2.3 (− 3.5, − 1.2)], and disability [73%; MD (95% CI): − 4.5 (− 6.1, − 2.9)] at 1-month follow-up. ISF-NF training is a feasible, safe, and an acceptable treatment approach for CLBP.https://doi.org/10.1038/s41598-023-28344-2 |
| spellingShingle | Divya Bharatkumar Adhia Ramakrishnan Mani Jerin Mathew Finella O’Leary Mark Smith Sven Vanneste Dirk De Ridder Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial Scientific Reports |
| title | Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial |
| title_full | Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial |
| title_fullStr | Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial |
| title_full_unstemmed | Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial |
| title_short | Exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain: a double-blinded safety and feasibility randomized placebo-controlled trial |
| title_sort | exploring electroencephalographic infraslow neurofeedback treatment for chronic low back pain a double blinded safety and feasibility randomized placebo controlled trial |
| url | https://doi.org/10.1038/s41598-023-28344-2 |
| work_keys_str_mv | AT divyabharatkumaradhia exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT ramakrishnanmani exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT jerinmathew exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT finellaoleary exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT marksmith exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT svenvanneste exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial AT dirkderidder exploringelectroencephalographicinfraslowneurofeedbacktreatmentforchroniclowbackpainadoubleblindedsafetyandfeasibilityrandomizedplacebocontrolledtrial |