[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma
Abstract Background Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We conducted a retrospective comparative analy...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-12-01
|
| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13550-023-01056-4 |
| _version_ | 1827399331000352768 |
|---|---|
| author | Peter Iversen Stine Kramer Andreas Ebbehoj Esben Søndergaard Kirstine Stochholm Per Løgstrup Poulsen Karin Hjorthaug |
| author_facet | Peter Iversen Stine Kramer Andreas Ebbehoj Esben Søndergaard Kirstine Stochholm Per Løgstrup Poulsen Karin Hjorthaug |
| author_sort | Peter Iversen |
| collection | DOAJ |
| description | Abstract Background Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We conducted a retrospective comparative analysis of FDOPA and DOTATOC to assess their sensitivity and accuracy in detecting PPGL when administered based on suspicion of PPGL. We consecutively included patients referred on suspicion of PPGL or PPGL recurrence who were scanned with both FDOPA and DOTATOC. Both scans were reviewed retrospectively by two experienced observers, who were blinded to the final diagnosis. The assessment was made both visually and quantitatively. The final diagnosis was primarily based on pathology. Results In total, 113 patients were included (97 suspected of primary PPGL and 16 suspected of recurrence). Of the 97 patients, 51 had pheochromocytomas (PCC) (in total 55 lesions) and 6 had paragangliomas (PGL) (in total 7 lesions). FDOPA detected and correctly localized all 55 PCC, while DOTATOC only detected 25 (sensitivity 100% vs. 49%, p < 0.0001; specificity 95% vs. 98%, p = 1.00). The negative predictive value (100% vs. 63%, p < 0.001) and diagnostic accuracy (98% vs. 70%, p < 0.01) were higher for FDOPA compared to DOTATOC. FDOPA identified 6 of 6 patients with hormone producing PGL, of which one was negative on DOTATOC. Diagnostic performances of FDOPA and DOTATOC were similar in the 16 patients with previous PPGL suspected of recurrence. Conclusions FDOPA is superior to DOTATOC for localization of PCC. In contrast to DOTATOC, FDOPA also identified all PGL but with a limited number of patient cases. |
| first_indexed | 2024-03-08T19:43:24Z |
| format | Article |
| id | doaj.art-6342e1f9b895447996544d06d52995b5 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-03-08T19:43:24Z |
| publishDate | 2023-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-6342e1f9b895447996544d06d52995b52023-12-24T12:29:03ZengSpringerOpenEJNMMI Research2191-219X2023-12-0113111010.1186/s13550-023-01056-4[18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytomaPeter Iversen0Stine Kramer1Andreas Ebbehoj2Esben Søndergaard3Kirstine Stochholm4Per Løgstrup Poulsen5Karin Hjorthaug6Department of Nuclear Medicine and PET Centre, Aarhus University HospitalDepartment of Nuclear Medicine and PET Centre, Aarhus University HospitalDepartment of Endocrinology and Internal Medicine, Aarhus University HospitalDepartment of Endocrinology and Internal Medicine, Aarhus University HospitalDepartment of Endocrinology and Internal Medicine, Aarhus University HospitalDepartment of Endocrinology and Internal Medicine, Aarhus University HospitalDepartment of Nuclear Medicine and PET Centre, Aarhus University HospitalAbstract Background Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only available in small series. We conducted a retrospective comparative analysis of FDOPA and DOTATOC to assess their sensitivity and accuracy in detecting PPGL when administered based on suspicion of PPGL. We consecutively included patients referred on suspicion of PPGL or PPGL recurrence who were scanned with both FDOPA and DOTATOC. Both scans were reviewed retrospectively by two experienced observers, who were blinded to the final diagnosis. The assessment was made both visually and quantitatively. The final diagnosis was primarily based on pathology. Results In total, 113 patients were included (97 suspected of primary PPGL and 16 suspected of recurrence). Of the 97 patients, 51 had pheochromocytomas (PCC) (in total 55 lesions) and 6 had paragangliomas (PGL) (in total 7 lesions). FDOPA detected and correctly localized all 55 PCC, while DOTATOC only detected 25 (sensitivity 100% vs. 49%, p < 0.0001; specificity 95% vs. 98%, p = 1.00). The negative predictive value (100% vs. 63%, p < 0.001) and diagnostic accuracy (98% vs. 70%, p < 0.01) were higher for FDOPA compared to DOTATOC. FDOPA identified 6 of 6 patients with hormone producing PGL, of which one was negative on DOTATOC. Diagnostic performances of FDOPA and DOTATOC were similar in the 16 patients with previous PPGL suspected of recurrence. Conclusions FDOPA is superior to DOTATOC for localization of PCC. In contrast to DOTATOC, FDOPA also identified all PGL but with a limited number of patient cases.https://doi.org/10.1186/s13550-023-01056-4FDOPADOTATOCPheochromocytomaParagangliomaPETPPGL |
| spellingShingle | Peter Iversen Stine Kramer Andreas Ebbehoj Esben Søndergaard Kirstine Stochholm Per Løgstrup Poulsen Karin Hjorthaug [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma EJNMMI Research FDOPA DOTATOC Pheochromocytoma Paraganglioma PET PPGL |
| title | [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma |
| title_full | [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma |
| title_fullStr | [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma |
| title_full_unstemmed | [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma |
| title_short | [18F]FDOPA PET/CT is superior to [68Ga]DOTATOC PET/CT in diagnostic imaging of pheochromocytoma |
| title_sort | 18f fdopa pet ct is superior to 68ga dotatoc pet ct in diagnostic imaging of pheochromocytoma |
| topic | FDOPA DOTATOC Pheochromocytoma Paraganglioma PET PPGL |
| url | https://doi.org/10.1186/s13550-023-01056-4 |
| work_keys_str_mv | AT peteriversen 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT stinekramer 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT andreasebbehoj 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT esbensøndergaard 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT kirstinestochholm 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT perløgstruppoulsen 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma AT karinhjorthaug 18ffdopapetctissuperiorto68gadotatocpetctindiagnosticimagingofpheochromocytoma |