Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified by the formation of an injury scar. While this scar was traditionally believed to be primarily responsible for axonal regeneration failure, current knowledge takes a more holistic approach that considers th...

Full description

Bibliographic Details
Main Authors:	Areez Shafqat, Ibrahem Albalkhi, Hamzah M. Magableh, Tariq Saleh, Khaled Alkattan, Ahmed Yaqinuddin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	spinal cord injury axonal regeneration glial scar neuroinflammation astrocyte heterogeneity microglia heterogeneity
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1180825/full

Similar Items

Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
by: Jingwei Zheng, et al.
Published: (2023-08-01)

Effects of electroacupuncture combined with hydrogel on the formation and changes in the glial scar in rats with spinal cord injury
by: Kaitan Yang, et al.
Published: (2022-04-01)

Understanding the Role of the Glial Scar through the Depletion of Glial Cells after Spinal Cord Injury
by: Lucila Perez-Gianmarco, et al.
Published: (2023-07-01)

Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury
by: Lili Quan, et al.
Published: (2025-01-01)

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury
by: María Belén Cieri, et al.
Published: (2025-04-01)

Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage
by: Jose A. Fernández-Albarral, et al.
Published: (2024-01-01)

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction
by: Yousef Tizabi, et al.
Published: (2024-05-01)

Chirality-Dependent Anti-Inflammatory Effect of Glutathione after Spinal Cord Injury in an Animal Model
by: Seong-Jun Kim, et al.
Published: (2021-08-01)

Current Advancements in Spinal Cord Injury Research—Glial Scar Formation and Neural Regeneration
by: Tanner Clifford, et al.
Published: (2023-03-01)

Editorial: Restoring neural circuits after spinal cord injury
by: Aikeremujiang Muheremu, et al.
Published: (2024-06-01)

Resident immune responses to spinal cord injury: role of astrocytes and microglia
by: Sydney Brockie, et al.
Published: (2024-01-01)

Evaluating Chondroitin Sulfate and Dermatan Sulfate Expression in Glial Scar to Determine Appropriate Intervention Time in Rats
by: Sara Rezaei, et al.
Published: (2020-01-01)

Ginsenoside Rb1 attenuates lipopolysaccharide-induced chronic neuroinflammation in mice by tuning glial cell polarization
by: Yushu Liu, et al.
Published: (2022-10-01)

Specific necroptosis inhibitor-1(Nec-1) attenuates glial scar formation in rat models with spinal cord injury
by: CHEN Sheng, WANG Chun-ming, YAN Xue-fei, MAO Yuan-qing
Published: (2022-01-01)

Editorial: Glial crosstalk in neurological disorders
by: Ikuko Miyazaki, et al.
Published: (2024-11-01)

Plasma Cytokines Level and Spinal Cord MRI Predict Clinical Outcome in a Rat Glial Scar Cryoinjury Model
by: Georgii B. Telegin, et al.
Published: (2022-09-01)

NF-κB and JAK/STAT Signaling Pathways as Crucial Regulators of Neuroinflammation and Astrocyte Modulation in Spinal Cord Injury
by: Tatyana Ageeva, et al.
Published: (2024-03-01)

Differential activation of spinal and parabrachial glial cells in a neuropathic pain model
by: Valeria Mussetto, et al.
Published: (2023-04-01)

Cathelicidin-Related Antimicrobial Peptide Negatively Regulates Bacterial Endotoxin-Induced Glial Activation
by: Anup Bhusal, et al.
Published: (2022-12-01)

Contribution of Central and Peripheral Glial Cells in the Development and Persistence of Itch: Therapeutic Implication of Glial Modulation
by: Parisa Gazerani
Published: (2023-01-01)

Immediate Early Gene c-fos in the Brain: Focus on Glial Cells
by: Fernando Cruz-Mendoza, et al.
Published: (2022-05-01)

Editorial: New insights into the role of neuroinflammation and glial cells in the development of neurological disorders
by: Marta Pérez-González, et al.
Published: (2023-03-01)

A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects
by: Ermei Lu, et al.
Published: (2025-01-01)

Editorial: 15 years of Frontiers in Cellular Neuroscience: the role of glial cells in schizophrenia and other related disorders
by: Hai-Ying Shen
Published: (2024-09-01)

Glial Contributions to Lafora Disease: A Systematic Review
by: Stefania Della Vecchia, et al.
Published: (2022-12-01)

Acid-Sensing Ion Channels in Glial Cells
by: Victoria Cegielski, et al.
Published: (2022-01-01)

Glial Populations in the Human Brain Following Ischemic Injury
by: Victoria Mihailova, et al.
Published: (2023-08-01)

Molecular Mechanisms in the Vascular and Nervous Systems following Traumatic Spinal Cord Injury
by: Shuo Li, et al.
Published: (2022-12-01)

Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid
by: Yen N. Diep, et al.
Published: (2023-07-01)

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord
by: Yali Chen, et al.
Published: (2025-11-01)

Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies
by: Giulia Magni, et al.
Published: (2024-03-01)

Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture
by: Tomoki Minamihata, et al.
Published: (2024-07-01)

Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression
by: Kalee N. Holloway, et al.
Published: (2023-02-01)

Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease
by: Jiao Fu, et al.
Published: (2025-02-01)

Neurological Impact of Respiratory Viruses: Insights into Glial Cell Responses in the Central Nervous System
by: Valentina P. Mora, et al.
Published: (2024-08-01)

Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
by: Elif O. Dogan, et al.
Published: (2023-12-01)

Mesenchymal Stem Cells Combined With Electroacupuncture Treatment Regulate the Subpopulation of Macrophages and Astrocytes to Facilitate Axonal Regeneration in Transected Spinal Cord
by: Rongyi Zhang, et al.
Published: (2023-12-01)

Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective
by: Jia-Jun Ju, et al.
Published: (2025-01-01)

Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice
by: Diéssica Padilha Dalenogare, et al.
Published: (2023-05-01)

Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders
by: Natalie Kaminsky, et al.
Published: (2016-06-01)