Strong Hereditary Predispositions to Colorectal Cancer
Cancer is one of the most common causes of death worldwide. A strong predisposition to cancer is generally only observed in colorectal cancer (5% of cases) and breast cancer (2% of cases). Colorectal cancer is the most common cancer with a strong genetic predisposition, but it includes dozens of var...
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MDPI AG
2022-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/12/2326 |
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| author | Szymon Hryhorowicz Marta Kaczmarek-Ryś Emilia Lis-Tanaś Jakub Porowski Marcin Szuman Natalia Grot Alicja Kryszczyńska Jacek Paszkowski Tomasz Banasiewicz Andrzej Pławski |
| author_facet | Szymon Hryhorowicz Marta Kaczmarek-Ryś Emilia Lis-Tanaś Jakub Porowski Marcin Szuman Natalia Grot Alicja Kryszczyńska Jacek Paszkowski Tomasz Banasiewicz Andrzej Pławski |
| author_sort | Szymon Hryhorowicz |
| collection | DOAJ |
| description | Cancer is one of the most common causes of death worldwide. A strong predisposition to cancer is generally only observed in colorectal cancer (5% of cases) and breast cancer (2% of cases). Colorectal cancer is the most common cancer with a strong genetic predisposition, but it includes dozens of various syndromes. This group includes familial adenomatous polyposis, attenuated familial adenomatous polyposis, <i>MUTYH</i>-associated polyposis, <i>NTHL1</i>-associated polyposis, Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, Lynch syndrome, and Muir–Torre syndrome. The common symptom of all these diseases is a very high risk of colorectal cancer, but depending on the condition, their course is different in terms of age and range of cancer occurrence. The rate of cancer development is determined by its conditioning genes, too. Hereditary predispositions to cancer of the intestine are a group of symptoms of heterogeneous diseases, and their proper diagnosis is crucial for the appropriate management of patients and their successful treatment. Mutations of specific genes cause strong colorectal cancer predispositions. Identifying mutations of predisposing genes will support proper diagnosis and application of appropriate screening programs to avoid malignant neoplasm. |
| first_indexed | 2024-03-09T16:28:26Z |
| format | Article |
| id | doaj.art-6349ecb37f1c49a8a354ba5488439a0a |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:28:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-6349ecb37f1c49a8a354ba5488439a0a2023-11-24T15:05:01ZengMDPI AGGenes2073-44252022-12-011312232610.3390/genes13122326Strong Hereditary Predispositions to Colorectal CancerSzymon Hryhorowicz0Marta Kaczmarek-Ryś1Emilia Lis-Tanaś2Jakub Porowski3Marcin Szuman4Natalia Grot5Alicja Kryszczyńska6Jacek Paszkowski7Tomasz Banasiewicz8Andrzej Pławski9Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandDepartment of General and Endocrine Surgery and Gastroenterological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, PolandDepartment of General and Endocrine Surgery and Gastroenterological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, PolandInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, PolandCancer is one of the most common causes of death worldwide. A strong predisposition to cancer is generally only observed in colorectal cancer (5% of cases) and breast cancer (2% of cases). Colorectal cancer is the most common cancer with a strong genetic predisposition, but it includes dozens of various syndromes. This group includes familial adenomatous polyposis, attenuated familial adenomatous polyposis, <i>MUTYH</i>-associated polyposis, <i>NTHL1</i>-associated polyposis, Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, Lynch syndrome, and Muir–Torre syndrome. The common symptom of all these diseases is a very high risk of colorectal cancer, but depending on the condition, their course is different in terms of age and range of cancer occurrence. The rate of cancer development is determined by its conditioning genes, too. Hereditary predispositions to cancer of the intestine are a group of symptoms of heterogeneous diseases, and their proper diagnosis is crucial for the appropriate management of patients and their successful treatment. Mutations of specific genes cause strong colorectal cancer predispositions. Identifying mutations of predisposing genes will support proper diagnosis and application of appropriate screening programs to avoid malignant neoplasm.https://www.mdpi.com/2073-4425/13/12/2326CRCCSFAPHNPCCJPSMTS |
| spellingShingle | Szymon Hryhorowicz Marta Kaczmarek-Ryś Emilia Lis-Tanaś Jakub Porowski Marcin Szuman Natalia Grot Alicja Kryszczyńska Jacek Paszkowski Tomasz Banasiewicz Andrzej Pławski Strong Hereditary Predispositions to Colorectal Cancer Genes CRC CS FAP HNPCC JPS MTS |
| title | Strong Hereditary Predispositions to Colorectal Cancer |
| title_full | Strong Hereditary Predispositions to Colorectal Cancer |
| title_fullStr | Strong Hereditary Predispositions to Colorectal Cancer |
| title_full_unstemmed | Strong Hereditary Predispositions to Colorectal Cancer |
| title_short | Strong Hereditary Predispositions to Colorectal Cancer |
| title_sort | strong hereditary predispositions to colorectal cancer |
| topic | CRC CS FAP HNPCC JPS MTS |
| url | https://www.mdpi.com/2073-4425/13/12/2326 |
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