Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study)
Introduction: In Germany, stroke is the third leading cause of death, with more than 60,000 fatalities out of approximately 260,000 cases (first-ever and recurrent strokes) each year. So far, there are only a few long-term studies investigating determinants of the natural course of the disease, espe...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/6/280 |
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| author | Michael Ertl Christa Meisinger Jakob Linseisen Sebastian-Edgar Baumeister Philipp Zickler Markus Naumann |
| author_facet | Michael Ertl Christa Meisinger Jakob Linseisen Sebastian-Edgar Baumeister Philipp Zickler Markus Naumann |
| author_sort | Michael Ertl |
| collection | DOAJ |
| description | Introduction: In Germany, stroke is the third leading cause of death, with more than 60,000 fatalities out of approximately 260,000 cases (first-ever and recurrent strokes) each year. So far, there are only a few long-term studies investigating determinants of the natural course of the disease, especially in the era of mechanical thrombectomy. Materials and Methods: The prospective single-center stroke cohort Augsburg (SCHANA) study will include about 1000 patients treated for stroke in the University Hospital of Augsburg. Patients aged 18 years or older with a confirmed diagnosis of ischemic or hemorrhagic stroke are included in the study. Information on demographic characteristics, onset of symptoms, etiologic factors, comorbidities, quality of life, invasive and non-invasive treatment, complications, and laboratory parameters are collected during a personal interview conducted during the patients’ hospital stay and via a medical chart review. About 30 mL of blood is collected from each patient, and after processing and aliquoting, all blood specimens are frozen at −80° C. The study participants will be followed-up via postal questionnaires at three and 12 months after discharge from the hospital. Furthermore, mortality follow-ups will be conducted. Cox-regression analysis will be used to estimate relative risks. Conclusion: The SCHANA study will generate comprehensive data on the long-term course of the disease. In addition to the main outcomes, recurrent events and survival, patient-oriented outcomes such as health-related quality of life and depression are the focus of the study. |
| first_indexed | 2024-03-12T11:01:27Z |
| format | Article |
| id | doaj.art-634c05b025fe4452b89d978386a4d943 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:01:27Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-634c05b025fe4452b89d978386a4d9432023-09-02T05:37:41ZengMDPI AGMedicina1010-660X2020-06-015628028010.3390/medicina56060280Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study)Michael Ertl0Christa Meisinger1Jakob Linseisen2Sebastian-Edgar Baumeister3Philipp Zickler4Markus Naumann5Department of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, GermanyIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, GermanyIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, GermanyIndependent Research Group Clinical Epidemiology, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, GermanyDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, GermanyDepartment of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, GermanyIntroduction: In Germany, stroke is the third leading cause of death, with more than 60,000 fatalities out of approximately 260,000 cases (first-ever and recurrent strokes) each year. So far, there are only a few long-term studies investigating determinants of the natural course of the disease, especially in the era of mechanical thrombectomy. Materials and Methods: The prospective single-center stroke cohort Augsburg (SCHANA) study will include about 1000 patients treated for stroke in the University Hospital of Augsburg. Patients aged 18 years or older with a confirmed diagnosis of ischemic or hemorrhagic stroke are included in the study. Information on demographic characteristics, onset of symptoms, etiologic factors, comorbidities, quality of life, invasive and non-invasive treatment, complications, and laboratory parameters are collected during a personal interview conducted during the patients’ hospital stay and via a medical chart review. About 30 mL of blood is collected from each patient, and after processing and aliquoting, all blood specimens are frozen at −80° C. The study participants will be followed-up via postal questionnaires at three and 12 months after discharge from the hospital. Furthermore, mortality follow-ups will be conducted. Cox-regression analysis will be used to estimate relative risks. Conclusion: The SCHANA study will generate comprehensive data on the long-term course of the disease. In addition to the main outcomes, recurrent events and survival, patient-oriented outcomes such as health-related quality of life and depression are the focus of the study.https://www.mdpi.com/1010-660X/56/6/280strokehealth caremortalitycomplicationsrecurrencepatient cohort |
| spellingShingle | Michael Ertl Christa Meisinger Jakob Linseisen Sebastian-Edgar Baumeister Philipp Zickler Markus Naumann Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) Medicina stroke health care mortality complications recurrence patient cohort |
| title | Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) |
| title_full | Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) |
| title_fullStr | Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) |
| title_full_unstemmed | Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) |
| title_short | Long-Term Outcomes in Patients with Stroke after in-Hospital Treatment—Study Protocol of the Prospective Stroke Cohort Augsburg (SCHANA Study) |
| title_sort | long term outcomes in patients with stroke after in hospital treatment study protocol of the prospective stroke cohort augsburg schana study |
| topic | stroke health care mortality complications recurrence patient cohort |
| url | https://www.mdpi.com/1010-660X/56/6/280 |
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