Novel Possible Biomarkers for the Cardiovascular Disease Prognosis
Background: Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-04-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/article-1-445-en.html |
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| author | Virna Margarita Martín Giménez Raúl Lelio Sanz Luciana Jorgelina Mazzei Roberto Bonafede Walter Manucha |
| author_facet | Virna Margarita Martín Giménez Raúl Lelio Sanz Luciana Jorgelina Mazzei Roberto Bonafede Walter Manucha |
| author_sort | Virna Margarita Martín Giménez |
| collection | DOAJ |
| description | Background: Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology and other related CVD has been revalued.
Objectives: This study was done to quantify and evaluate inflammatory markers, such as ultra-sensitive C-reactive protein (uCRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and heat shock protein 70 (Hsp70) in the serum of patients with HF and to compare them with healthy individuals, also correlate the values obtained from oxidative stress markers and nitric oxide (NO) bioavailability previously investigated in these patients with the coexistence or not of secondary pulmonary hypertension (SPH) associated with HF.
Methods: The determination of all parameters was achieved with standardized, reproducible, accurate, and affordable biochemical methods.
Results: The values obtained for uCRP, IL-6, and TNF-α were following the pattern of oxidative markers previously found in these patients. These findings indicate the coexistence of oxidative stress and inflammation during HF. Of particular interest, such markers are more exacerbated when were associated with SPH, increasing its value as possible biomarkers in this pathology. However, the found levels of Hsp70 were controversial.
Conclusion: The pattern of oxidative-inflammatory markers suggests their value as possible biomarkers in this cardiovascular disease. Nevertheless, additional studies are needed to assess in greater detail the importance of the relationship between serum Hsp70 expression and SPH-associated or non-SPH morbidity in HF. |
| first_indexed | 2024-04-11T22:10:00Z |
| format | Article |
| id | doaj.art-635156f58e0644408aab16ed13043bf1 |
| institution | Directory Open Access Journal |
| issn | 2423-4494 |
| language | English |
| last_indexed | 2024-04-11T22:10:00Z |
| publishDate | 2022-04-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-635156f58e0644408aab16ed13043bf12022-12-22T04:00:36ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44942022-04-0182143154Novel Possible Biomarkers for the Cardiovascular Disease PrognosisVirna Margarita Martín Giménez0Raúl Lelio Sanz1Luciana Jorgelina Mazzei2Roberto Bonafede3Walter Manucha4 Chemical Sciences Research Institute, Faculty of Chemical and Technological Sciences, Catholic University of Cuyo, San Juan, Mendoza, Argentina. Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina. Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina. Heart Failure Unit, Cardiology Service, Mendoza Central Hospital, Mendoza, Argentina. Faculty of Medical Sciences, National University of Cuyo, Mendoza, Argentina. Background: Cardiovascular disease (CVD), especially heart failure (HF) as its common final pathway, is the leading cause of morbidity and mortality worldwide. Furthermore, oxidative and inflammatory processes represent fundamental underlying mechanisms for the development and progression of HF. Of interest, in recent years the development of markers with diagnostic and prognostic value for this pathology and other related CVD has been revalued. Objectives: This study was done to quantify and evaluate inflammatory markers, such as ultra-sensitive C-reactive protein (uCRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and heat shock protein 70 (Hsp70) in the serum of patients with HF and to compare them with healthy individuals, also correlate the values obtained from oxidative stress markers and nitric oxide (NO) bioavailability previously investigated in these patients with the coexistence or not of secondary pulmonary hypertension (SPH) associated with HF. Methods: The determination of all parameters was achieved with standardized, reproducible, accurate, and affordable biochemical methods. Results: The values obtained for uCRP, IL-6, and TNF-α were following the pattern of oxidative markers previously found in these patients. These findings indicate the coexistence of oxidative stress and inflammation during HF. Of particular interest, such markers are more exacerbated when were associated with SPH, increasing its value as possible biomarkers in this pathology. However, the found levels of Hsp70 were controversial. Conclusion: The pattern of oxidative-inflammatory markers suggests their value as possible biomarkers in this cardiovascular disease. Nevertheless, additional studies are needed to assess in greater detail the importance of the relationship between serum Hsp70 expression and SPH-associated or non-SPH morbidity in HF.http://pbr.mazums.ac.ir/article-1-445-en.htmlheart failurepulmonary hypertensionc-reactive proteinheat-shock protein 70biomarkers |
| spellingShingle | Virna Margarita Martín Giménez Raúl Lelio Sanz Luciana Jorgelina Mazzei Roberto Bonafede Walter Manucha Novel Possible Biomarkers for the Cardiovascular Disease Prognosis Pharmaceutical and Biomedical Research heart failure pulmonary hypertension c-reactive protein heat-shock protein 70 biomarkers |
| title | Novel Possible Biomarkers for the Cardiovascular Disease Prognosis |
| title_full | Novel Possible Biomarkers for the Cardiovascular Disease Prognosis |
| title_fullStr | Novel Possible Biomarkers for the Cardiovascular Disease Prognosis |
| title_full_unstemmed | Novel Possible Biomarkers for the Cardiovascular Disease Prognosis |
| title_short | Novel Possible Biomarkers for the Cardiovascular Disease Prognosis |
| title_sort | novel possible biomarkers for the cardiovascular disease prognosis |
| topic | heart failure pulmonary hypertension c-reactive protein heat-shock protein 70 biomarkers |
| url | http://pbr.mazums.ac.ir/article-1-445-en.html |
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