Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy

Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy

Developing new therapeutic agents for cancer immunotherapy is highly demanding due to the low response ratio of PD-1/PD-L1 blockade in cancer patients. Here, we discovered that the novel immune checkpoint VISTA is highly expressed on a variety of tumor-infiltrating immune cells, especially myeloid d...

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Bibliographic Details
Main Authors: Xiaoshuang Niu, Menghan Wu, Guodong Li, Xiuman Zhou, Wenpeng Cao, Wenjie Zhai, Aijun Wu, Xiaowen Zhou, Shengzhe Jin, Guanyu Chen, Yanying Li, Jiangfeng Du, Yahong Wu, Lu Qiu, Wenshan Zhao, Yanfeng Gao
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Immune checkpoint
VISTA
PSGL-1
Phage displayed bio-panning
Peptide
Cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002940

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