Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling

Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of Pituitary Adenoma Cells by Hampering Oncogenic Pathways and Promoting Apoptotic Signaling

Pituitary adenomas (PAs) are intracranial tumors, often associated with excessive hormonal secretion and severe comorbidities. Some patients are resistant to medical therapies; therefore, novel treatment options are needed. Antagonists of growth hormone-releasing hormone (GHRH) exert potent anticanc...

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Bibliographic Details
Main Authors: Iacopo Gesmundo, Giuseppina Granato, Antonio C. Fuentes-Fayos, Clara V. Alvarez, Carlos Dieguez, Maria Chiara Zatelli, Noemi Congiusta, Dana Banfi, Nunzia Prencipe, Sheila Leone, Luigi Brunetti, Justo P. Castaño, Raúl M. Luque, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, Riccarda Granata
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
GHRH
GH-secreting pituitary adenoma
ACTH-secreting pituitary adenomas
cell viability
apoptosis
Online Access:https://www.mdpi.com/2072-6694/13/16/3950

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