Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children
In recent decades, magnetically controlled growing rods (MCGR) were established to treat progressive early-onset scoliosis. The aim of this investigation was to assess the effect of long-term MCGR with continuous distraction on intervertebral discs in scoliotic children. Magnetic resonance imaging (...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/10/2124 |
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| author | Sebastian Lippross Paul Girmond Katja A. Lüders Friederike Austein Lena Braunschweig Stefan Lüders Konstantinos Tsaknakis Heiko M. Lorenz Anna K. Hell |
| author_facet | Sebastian Lippross Paul Girmond Katja A. Lüders Friederike Austein Lena Braunschweig Stefan Lüders Konstantinos Tsaknakis Heiko M. Lorenz Anna K. Hell |
| author_sort | Sebastian Lippross |
| collection | DOAJ |
| description | In recent decades, magnetically controlled growing rods (MCGR) were established to treat progressive early-onset scoliosis. The aim of this investigation was to assess the effect of long-term MCGR with continuous distraction on intervertebral discs in scoliotic children. Magnetic resonance imaging (MRI) of 33 children with spinal muscular atrophy was analyzed by grading intervertebral disc degeneration (IDD) and measuring intervertebral disc volume. Cohort I (<i>n</i> = 17) were children who had continuous spinal distraction with MCGRs for 5.1 years and MRI before (av. age 8.1) and after (av. age 13.4) MCGR treatment. Cohort II (<i>n</i> = 16, av. age 13.7) were patients without prior surgical treatment. Lumbar intervertebral disc volume of cohort I did not change during 5.1 years of MCGR treatment, whereas disc volumes were significantly larger in age- and disease-matched children without prior treatment (cohort II). Cohort I showed more IDD after MCGR treatment in comparison to early MRI studies of the same patients and children without surgical treatment. MRI data showed a volume reduction and disc degeneration of lower thoracic and lumbar intervertebral discs in scoliotic children after continuous spinal distraction with MCGRs. These effects were confirmed in the same subjects before and after treatment as well as in surgically untreated controls. |
| first_indexed | 2024-03-10T11:24:50Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T11:24:50Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-63535edf277b4d48828bd2e338f8b9602023-11-21T19:42:59ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011010212410.3390/jcm10102124Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic ChildrenSebastian Lippross0Paul Girmond1Katja A. Lüders2Friederike Austein3Lena Braunschweig4Stefan Lüders5Konstantinos Tsaknakis6Heiko M. Lorenz7Anna K. Hell8Department of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyDepartment of Orthopedic and Trauma Surgery, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, GermanyDepartment of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyMahr GmbH, 37073 Goettingen, GermanyDepartment of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyDepartment of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyDepartment of Trauma, Orthopedic and Plastic Surgery, University Medical Center Goettingen, 37075 Goettingen, GermanyIn recent decades, magnetically controlled growing rods (MCGR) were established to treat progressive early-onset scoliosis. The aim of this investigation was to assess the effect of long-term MCGR with continuous distraction on intervertebral discs in scoliotic children. Magnetic resonance imaging (MRI) of 33 children with spinal muscular atrophy was analyzed by grading intervertebral disc degeneration (IDD) and measuring intervertebral disc volume. Cohort I (<i>n</i> = 17) were children who had continuous spinal distraction with MCGRs for 5.1 years and MRI before (av. age 8.1) and after (av. age 13.4) MCGR treatment. Cohort II (<i>n</i> = 16, av. age 13.7) were patients without prior surgical treatment. Lumbar intervertebral disc volume of cohort I did not change during 5.1 years of MCGR treatment, whereas disc volumes were significantly larger in age- and disease-matched children without prior treatment (cohort II). Cohort I showed more IDD after MCGR treatment in comparison to early MRI studies of the same patients and children without surgical treatment. MRI data showed a volume reduction and disc degeneration of lower thoracic and lumbar intervertebral discs in scoliotic children after continuous spinal distraction with MCGRs. These effects were confirmed in the same subjects before and after treatment as well as in surgically untreated controls.https://www.mdpi.com/2077-0383/10/10/2124intervertebral discvolumedisc degenerationspinal muscular atrophyscoliosisgrowth-friendly implants |
| spellingShingle | Sebastian Lippross Paul Girmond Katja A. Lüders Friederike Austein Lena Braunschweig Stefan Lüders Konstantinos Tsaknakis Heiko M. Lorenz Anna K. Hell Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children Journal of Clinical Medicine intervertebral disc volume disc degeneration spinal muscular atrophy scoliosis growth-friendly implants |
| title | Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children |
| title_full | Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children |
| title_fullStr | Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children |
| title_full_unstemmed | Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children |
| title_short | Smaller Intervertebral Disc Volume and More Disc Degeneration after Spinal Distraction in Scoliotic Children |
| title_sort | smaller intervertebral disc volume and more disc degeneration after spinal distraction in scoliotic children |
| topic | intervertebral disc volume disc degeneration spinal muscular atrophy scoliosis growth-friendly implants |
| url | https://www.mdpi.com/2077-0383/10/10/2124 |
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