A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo
Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/362 |
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| author | Fairouz Sioud Souheila Amor Imène ben Toumia Aida Lahmar Virginie Aires Leila Chekir-Ghedira Dominique Delmas |
| author_facet | Fairouz Sioud Souheila Amor Imène ben Toumia Aida Lahmar Virginie Aires Leila Chekir-Ghedira Dominique Delmas |
| author_sort | Fairouz Sioud |
| collection | DOAJ |
| description | Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially for some anticancer drugs such as cisplatin, which induces a nephrotoxicity. In the strategy of research for active molecules capable both of exerting a protective action against the deleterious effects of cisplatin and exerting a chemosensitizing action with regard to cancer cells, we tested the potential effects of <i>Ephedra alata</i> Decne extract (E.A.) rich in polyphenolic compounds towards a 4T1 breast cancer model in vitro and in vivo. We showed that E.A. extract inhibited cell viability of 4T1 breast cancer cells and induced apoptosis in a caspase-dependent manner, which involved intrinsic pathways. Very interestingly, we observed a synergic antiproliferative and pro-apoptotic action with cisplatin. These events were associated with a strong decrease of breast tumor growth in mice treated with an E.A./cisplatin combination and simultaneously with a decrease of hepato- and nephrotoxicities of cisplatin. |
| first_indexed | 2024-03-12T07:51:47Z |
| format | Article |
| id | doaj.art-6353cf0d99a2457f89262e8d79442f53 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:51:47Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6353cf0d99a2457f89262e8d79442f532023-09-02T20:31:50ZengMDPI AGCells2073-44092020-02-019236210.3390/cells9020362cells9020362A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In VivoFairouz Sioud0Souheila Amor1Imène ben Toumia2Aida Lahmar3Virginie Aires4Leila Chekir-Ghedira5Dominique Delmas6Research Unit Bioactive Natural Products and Biotechnology UR17ES49, Faculty of Dental Medicine of Monastir, University of Monastir, Avicenne street, Monastir 5000, TunisiaUniversité de Bourgogne Franche-Comté, F-21000 Dijon, FranceResearch Unit Bioactive Natural Products and Biotechnology UR17ES49, Faculty of Dental Medicine of Monastir, University of Monastir, Avicenne street, Monastir 5000, TunisiaResearch Unit Bioactive Natural Products and Biotechnology UR17ES49, Faculty of Dental Medicine of Monastir, University of Monastir, Avicenne street, Monastir 5000, TunisiaUniversité de Bourgogne Franche-Comté, F-21000 Dijon, FranceResearch Unit Bioactive Natural Products and Biotechnology UR17ES49, Faculty of Dental Medicine of Monastir, University of Monastir, Avicenne street, Monastir 5000, TunisiaUniversité de Bourgogne Franche-Comté, F-21000 Dijon, FranceDespite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially for some anticancer drugs such as cisplatin, which induces a nephrotoxicity. In the strategy of research for active molecules capable both of exerting a protective action against the deleterious effects of cisplatin and exerting a chemosensitizing action with regard to cancer cells, we tested the potential effects of <i>Ephedra alata</i> Decne extract (E.A.) rich in polyphenolic compounds towards a 4T1 breast cancer model in vitro and in vivo. We showed that E.A. extract inhibited cell viability of 4T1 breast cancer cells and induced apoptosis in a caspase-dependent manner, which involved intrinsic pathways. Very interestingly, we observed a synergic antiproliferative and pro-apoptotic action with cisplatin. These events were associated with a strong decrease of breast tumor growth in mice treated with an E.A./cisplatin combination and simultaneously with a decrease of hepato- and nephrotoxicities of cisplatin.https://www.mdpi.com/2073-4409/9/2/362<i>ephedra</i>cisplatinpolyphenolsbreast cancerchemosensibilisation |
| spellingShingle | Fairouz Sioud Souheila Amor Imène ben Toumia Aida Lahmar Virginie Aires Leila Chekir-Ghedira Dominique Delmas A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo Cells <i>ephedra</i> cisplatin polyphenols breast cancer chemosensibilisation |
| title | A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| title_full | A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| title_fullStr | A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| title_full_unstemmed | A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| title_short | A New Highlight of <i>Ephedra alata</i> Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo |
| title_sort | new highlight of i ephedra alata i decne properties as potential adjuvant in combination with cisplatin to induce cell death of 4t1 breast cancer cells in vitro and in vivo |
| topic | <i>ephedra</i> cisplatin polyphenols breast cancer chemosensibilisation |
| url | https://www.mdpi.com/2073-4409/9/2/362 |
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