Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults
Abstract Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ]4...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12419 |
| _version_ | 1797317318348374016 |
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| author | Jenna N. Adams Freddie Márquez Myra S. Larson John T. Janecek Blake A. Miranda Jessica A. Noche Lisa Taylor Martina K. Hollearn Liv McMillan David B. Keator Elizabeth Head Robert A. Rissman Michael A. Yassa |
| author_facet | Jenna N. Adams Freddie Márquez Myra S. Larson John T. Janecek Blake A. Miranda Jessica A. Noche Lisa Taylor Martina K. Hollearn Liv McMillan David B. Keator Elizabeth Head Robert A. Rissman Michael A. Yassa |
| author_sort | Jenna N. Adams |
| collection | DOAJ |
| description | Abstract Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ]42/Aβ40, phosphorylated tau [p‐tau]181, total tau [t‐tau]), positron emission tomography (PET; 18F‐florbetapir), high‐resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed. We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI). Results Biomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely associated with RI, whereas CA1 and BA35 volume were related to both RI and overall memory recall. AD pathology was associated with reduced BA35, CA1, and subiculum volume. DG volume and Aβ were independently associated with RI, whereas CA1 volume mediated the relationship between AD pathology and RI. Discussion Integrity of distinct hippocampal subfields demonstrate differential relationships with pathology and memory function, indicating specificity in vulnerability and contribution to different memory processes. |
| first_indexed | 2024-03-08T03:33:11Z |
| format | Article |
| id | doaj.art-63544acbb62d4127b59ca31494bb0f25 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-08T03:33:11Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-63544acbb62d4127b59ca31494bb0f252024-02-10T14:10:32ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-04-01152n/an/a10.1002/dad2.12419Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adultsJenna N. Adams0Freddie Márquez1Myra S. Larson2John T. Janecek3Blake A. Miranda4Jessica A. Noche5Lisa Taylor6Martina K. Hollearn7Liv McMillan8David B. Keator9Elizabeth Head10Robert A. Rissman11Michael A. Yassa12Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Psychiatry and Human Behavior University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USADepartment of Psychiatry and Human Behavior University of California Irvine California USADepartment of Pathology and Laboratory Medicine University of California Irvine California USADepartment of Neurosciences University of California San Diego California USADepartment of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory University of California Irvine California USAAbstract Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ]42/Aβ40, phosphorylated tau [p‐tau]181, total tau [t‐tau]), positron emission tomography (PET; 18F‐florbetapir), high‐resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed. We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI). Results Biomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely associated with RI, whereas CA1 and BA35 volume were related to both RI and overall memory recall. AD pathology was associated with reduced BA35, CA1, and subiculum volume. DG volume and Aβ were independently associated with RI, whereas CA1 volume mediated the relationship between AD pathology and RI. Discussion Integrity of distinct hippocampal subfields demonstrate differential relationships with pathology and memory function, indicating specificity in vulnerability and contribution to different memory processes.https://doi.org/10.1002/dad2.12419Alzheimer's diseaseamyloid‐betamedial temporal lobememoryneurodegenerationtau |
| spellingShingle | Jenna N. Adams Freddie Márquez Myra S. Larson John T. Janecek Blake A. Miranda Jessica A. Noche Lisa Taylor Martina K. Hollearn Liv McMillan David B. Keator Elizabeth Head Robert A. Rissman Michael A. Yassa Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease amyloid‐beta medial temporal lobe memory neurodegeneration tau |
| title | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
| title_full | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
| title_fullStr | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
| title_full_unstemmed | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
| title_short | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
| title_sort | differential involvement of hippocampal subfields in the relationship between alzheimer s pathology and memory interference in older adults |
| topic | Alzheimer's disease amyloid‐beta medial temporal lobe memory neurodegeneration tau |
| url | https://doi.org/10.1002/dad2.12419 |
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