Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma
Objective: To summarize and analyze the clinical data, computed tomography (CT) signs, and pathological features of bronchiolar adenoma, and to discuss the diagnostic value of bronchiolar adenoma. Methods: In total, 18 cases of pulmonary nodules diagnosed as bronchiolar adenoma via postoperative pat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Editorial Office of Computerized Tomography Theory and Application
2023-01-01
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| Series: | CT Lilun yu yingyong yanjiu |
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| Online Access: | https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2022.247 |
| _version_ | 1797359559523696640 |
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| author | Xiaohuan PAN Ping HE Huai CHEN |
| author_facet | Xiaohuan PAN Ping HE Huai CHEN |
| author_sort | Xiaohuan PAN |
| collection | DOAJ |
| description | Objective: To summarize and analyze the clinical data, computed tomography (CT) signs, and pathological features of bronchiolar adenoma, and to discuss the diagnostic value of bronchiolar adenoma. Methods: In total, 18 cases of pulmonary nodules diagnosed as bronchiolar adenoma via postoperative pathology from January 2020 to December 2020 were retrospectively collected, and the clinical data, chest CT signs, and postoperative pathological features of pulmonary nodules were analyzed. Results: Among the 18 cases, 16 had no clinical chest symptoms, and 2 had chest pain. The patients were 18~65 years old. The mean age was 51.8 years, and the median age (25％~75％ quantile) was 52 (49~59) years; 7 patients were male (39％), and 11 were females (61％). The average maximum slice diameter of bronchiolar adenoma was 11.1 mm, and the median diameter (25％~75％ quantile) was 8 (6~15) mm. There were 15 cases with lesion distance ≤10 mm from the pleura. CT showed that 8 cases were pure ground-glass nodules (pGGN), 7 cases were part-solid nodules (PSN), and 3 cases had simple cystic space. The mean CT value of bronchiolar adenomas presenting with pGGN was −690.7 HU. The median mean CT value (25％~75％ quantiles) was −717.5 (−722~ −681) HU. A spicule sign at the nodular margin was found in 6 of the 18 cases. Pleural traction around nodules was found in 7 cases, and bronchiectasis occurred in nodules in 5 cases. The postoperative gross pathological diameter of 18 nodules was 9.1 mm, and the median diameter (25％~75％ quantile) was 7 (6~9) mm. Pathological immunohistochemical antibody CK7 was positive in 18 cases; p40, p63, CK5/6, and TTF-1 were positive in 16 cases. Conclusions: Bronchiolar adenoma often occurs in middle-aged and older women. Preoperative CT diagnosis of subpleural nodules around 10 mm could indicate the disease, and immunohistochemical antibody CK7, p40, and other indicators are qualitative methods for diagnosing bronchiolar adenoma. |
| first_indexed | 2024-03-08T15:25:31Z |
| format | Article |
| id | doaj.art-63546c4fe7dc41d7b55e3d2543d1db04 |
| institution | Directory Open Access Journal |
| issn | 1004-4140 |
| language | English |
| last_indexed | 2024-03-08T15:25:31Z |
| publishDate | 2023-01-01 |
| publisher | Editorial Office of Computerized Tomography Theory and Application |
| record_format | Article |
| series | CT Lilun yu yingyong yanjiu |
| spelling | doaj.art-63546c4fe7dc41d7b55e3d2543d1db042024-01-10T09:27:14ZengEditorial Office of Computerized Tomography Theory and ApplicationCT Lilun yu yingyong yanjiu1004-41402023-01-01331566210.15953/j.ctta.2022.2472022.247Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar AdenomaXiaohuan PANPing HEHuai CHENObjective: To summarize and analyze the clinical data, computed tomography (CT) signs, and pathological features of bronchiolar adenoma, and to discuss the diagnostic value of bronchiolar adenoma. Methods: In total, 18 cases of pulmonary nodules diagnosed as bronchiolar adenoma via postoperative pathology from January 2020 to December 2020 were retrospectively collected, and the clinical data, chest CT signs, and postoperative pathological features of pulmonary nodules were analyzed. Results: Among the 18 cases, 16 had no clinical chest symptoms, and 2 had chest pain. The patients were 18~65 years old. The mean age was 51.8 years, and the median age (25％~75％ quantile) was 52 (49~59) years; 7 patients were male (39％), and 11 were females (61％). The average maximum slice diameter of bronchiolar adenoma was 11.1 mm, and the median diameter (25％~75％ quantile) was 8 (6~15) mm. There were 15 cases with lesion distance ≤10 mm from the pleura. CT showed that 8 cases were pure ground-glass nodules (pGGN), 7 cases were part-solid nodules (PSN), and 3 cases had simple cystic space. The mean CT value of bronchiolar adenomas presenting with pGGN was −690.7 HU. The median mean CT value (25％~75％ quantiles) was −717.5 (−722~ −681) HU. A spicule sign at the nodular margin was found in 6 of the 18 cases. Pleural traction around nodules was found in 7 cases, and bronchiectasis occurred in nodules in 5 cases. The postoperative gross pathological diameter of 18 nodules was 9.1 mm, and the median diameter (25％~75％ quantile) was 7 (6~9) mm. Pathological immunohistochemical antibody CK7 was positive in 18 cases; p40, p63, CK5/6, and TTF-1 were positive in 16 cases. Conclusions: Bronchiolar adenoma often occurs in middle-aged and older women. Preoperative CT diagnosis of subpleural nodules around 10 mm could indicate the disease, and immunohistochemical antibody CK7, p40, and other indicators are qualitative methods for diagnosing bronchiolar adenoma.https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2022.247computed tomographylung cancerbronchiolar adenomadiagnosis |
| spellingShingle | Xiaohuan PAN Ping HE Huai CHEN Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma CT Lilun yu yingyong yanjiu computed tomography lung cancer bronchiolar adenoma diagnosis |
| title | Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma |
| title_full | Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma |
| title_fullStr | Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma |
| title_full_unstemmed | Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma |
| title_short | Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma |
| title_sort | computed tomography findings and preliminary exploration of pathological analysis of bronchiolar adenoma |
| topic | computed tomography lung cancer bronchiolar adenoma diagnosis |
| url | https://www.cttacn.org.cn/cn/article/doi/10.15953/j.ctta.2022.247 |
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