Ovarian effects of vitamin D: a systematic review
The history of the discovery of vitamin D (VD) has crossed 100 years. Initially, VD deficiency was limitedly associated with the development of rickets in children. Later, on the basis of a number of studies, it was found that VD deficiency is a risk factor for osteoporosis in men and women. However...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2021-04-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/6072 |
| _version_ | 1827962276992253952 |
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| author | G. E. Chernukha O. V. Yakushevskaya |
| author_facet | G. E. Chernukha O. V. Yakushevskaya |
| author_sort | G. E. Chernukha |
| collection | DOAJ |
| description | The history of the discovery of vitamin D (VD) has crossed 100 years. Initially, VD deficiency was limitedly associated with the development of rickets in children. Later, on the basis of a number of studies, it was found that VD deficiency is a risk factor for osteoporosis in men and women. However, the traditional concept of VD as the main regulator of calcium-phosphorus metabolism has undergone dramatic changes over the past two decades. A prerequisite for revising the role of VD and the spectrum of its biological properties was the identification of the distribution of its specific receptors in the body. VD receptors are expressed in the intestine, thyroid and parathyroid glands, kidneys, ovaries, uterus, placenta, hypothalamus, pituitary gland and play a vital function not only in calcium homeostasis. Accordingly, the list of target organs for VD action has been modified. VD deficiency, calculated on a pandemic scale, is a factor that increases the risk of developing not only osteoporosis, but also a number of other diseases. Observational and epidemiological studies have shown that reproductive system disorders are very often combined with VD insufficiency / deficiency. Subsequent scientific research aimed at establishing the role of VD in the formation of a particular pathology of the reproductive system has shown very ambiguous results. VD is recognized as an essential component of maintaining a woman’s reproductive health. Of course, the presence of an established association is not evidence of a causal relationship. There is a need for additional testing. This review focuses on the effect of VD on ovarian function and the formation of various dysfunctional conditions. |
| first_indexed | 2024-04-09T16:40:10Z |
| format | Article |
| id | doaj.art-6355178ee26f491d9e4fc05d4f284a06 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:40:10Z |
| publishDate | 2021-04-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-6355178ee26f491d9e4fc05d4f284a062023-04-23T06:56:43ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-04-0103444910.21518/2079-701X-2021-3-44-495514Ovarian effects of vitamin D: a systematic reviewG. E. Chernukha0O. V. Yakushevskaya1Kulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyKulakov National Medical Research Center of Obstetrics, Gynecology and PerinatologyThe history of the discovery of vitamin D (VD) has crossed 100 years. Initially, VD deficiency was limitedly associated with the development of rickets in children. Later, on the basis of a number of studies, it was found that VD deficiency is a risk factor for osteoporosis in men and women. However, the traditional concept of VD as the main regulator of calcium-phosphorus metabolism has undergone dramatic changes over the past two decades. A prerequisite for revising the role of VD and the spectrum of its biological properties was the identification of the distribution of its specific receptors in the body. VD receptors are expressed in the intestine, thyroid and parathyroid glands, kidneys, ovaries, uterus, placenta, hypothalamus, pituitary gland and play a vital function not only in calcium homeostasis. Accordingly, the list of target organs for VD action has been modified. VD deficiency, calculated on a pandemic scale, is a factor that increases the risk of developing not only osteoporosis, but also a number of other diseases. Observational and epidemiological studies have shown that reproductive system disorders are very often combined with VD insufficiency / deficiency. Subsequent scientific research aimed at establishing the role of VD in the formation of a particular pathology of the reproductive system has shown very ambiguous results. VD is recognized as an essential component of maintaining a woman’s reproductive health. Of course, the presence of an established association is not evidence of a causal relationship. There is a need for additional testing. This review focuses on the effect of VD on ovarian function and the formation of various dysfunctional conditions.https://www.med-sovet.pro/jour/article/view/6072vitamin dfolliculogenesisovulationpolycystic ovary syndromepremature ovarian failureovarian cancer |
| spellingShingle | G. E. Chernukha O. V. Yakushevskaya Ovarian effects of vitamin D: a systematic review Медицинский совет vitamin d folliculogenesis ovulation polycystic ovary syndrome premature ovarian failure ovarian cancer |
| title | Ovarian effects of vitamin D: a systematic review |
| title_full | Ovarian effects of vitamin D: a systematic review |
| title_fullStr | Ovarian effects of vitamin D: a systematic review |
| title_full_unstemmed | Ovarian effects of vitamin D: a systematic review |
| title_short | Ovarian effects of vitamin D: a systematic review |
| title_sort | ovarian effects of vitamin d a systematic review |
| topic | vitamin d folliculogenesis ovulation polycystic ovary syndrome premature ovarian failure ovarian cancer |
| url | https://www.med-sovet.pro/jour/article/view/6072 |
| work_keys_str_mv | AT gechernukha ovarianeffectsofvitamindasystematicreview AT ovyakushevskaya ovarianeffectsofvitamindasystematicreview |