Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia
Elevated serum uric acid (UA) level is related to type 2 diabetic retinopathy (DR). Vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and cystatin C (Cys-C) have involvement in type 2 DR complicated with hyperuricemia (HUA) (HUDR), and we explored their clinica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-12-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2023-0857 |
| _version_ | 1797397413370003456 |
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| author | Wei Jing Zhang Jincheng Shi Yanan Zhang Huiqin Wu Yan |
| author_facet | Wei Jing Zhang Jincheng Shi Yanan Zhang Huiqin Wu Yan |
| author_sort | Wei Jing |
| collection | DOAJ |
| description | Elevated serum uric acid (UA) level is related to type 2 diabetic retinopathy (DR). Vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and cystatin C (Cys-C) have involvement in type 2 DR complicated with hyperuricemia (HUA) (HUDR), and we explored their clinical values in HUDR. Type 2 DR patients were allocated into HUDR/DR groups, with type 2 diabetes mellitus (T2DM) patients as the control group. Serum VEGF and inflammation markers hs-CRP, and Cys-C levels were assessed by ELISA and immunoturbidimetry. The correlations between serum UA level and VEGF/hs-CRP/Cys-C were analyzed by Pearson tests, diagnostic values of VEGF/hs-CRP/Cys-C were analyzed by receiver operating characteristic curves, and the independent risk factors in HUDR were analyzed by logistic multivariate regression. Serum VEGF/hs-CRP/Cys-C level differences among the T2DM/DR/HUDR groups were statistically significant, with the levels in HUDR > DR > T2DM. Serum UA level in HUDR patients was positively correlated with serum VEGF/hs-CRP/Cys-C. Serum VEGF/hs-CRP/Cys-C assisted in HUDR diagnosis, with their combination showing the greatest diagnostic value. UA/FPG/HbA1C/VEGF/hs-CRP/Cys-C were independent risk factors for HUDR. The incidence of proliferative DR was increased in HUDR patients. Collectively, serum VEGF, hs-CRP, and Cys-C levels in HUDR patients were increased, and HUA might promote DR progression. |
| first_indexed | 2024-03-09T01:09:34Z |
| format | Article |
| id | doaj.art-635589e1a75442fd912576cc6cf017f9 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-09T01:09:34Z |
| publishDate | 2023-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-635589e1a75442fd912576cc6cf017f92023-12-11T07:36:35ZengDe GruyterOpen Medicine2391-54632023-12-0118118166010.1515/med-2023-0857Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemiaWei Jing0Zhang Jincheng1Shi Yanan2Zhang Huiqin3Wu Yan4No.1 Department of Endocrinology, Cangzhou Central Hospital, Cangzhou City, Hebei Province, 061000, ChinaNo.1 Department of Endocrinology, Cangzhou Central Hospital, 16 West Xinhua Road, Cangzhou City, Hebei Province, 061000, ChinaNo.1 Department of Endocrinology, Cangzhou Central Hospital, Cangzhou City, Hebei Province, 061000, ChinaNo.1 Department of Ophthalmology, Cangzhou Central Hospital, Cangzhou City, Hebei Province, 061000, ChinaNo.1 Department of Endocrinology, Cangzhou Central Hospital, Cangzhou City, Hebei Province, 061000, ChinaElevated serum uric acid (UA) level is related to type 2 diabetic retinopathy (DR). Vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP), and cystatin C (Cys-C) have involvement in type 2 DR complicated with hyperuricemia (HUA) (HUDR), and we explored their clinical values in HUDR. Type 2 DR patients were allocated into HUDR/DR groups, with type 2 diabetes mellitus (T2DM) patients as the control group. Serum VEGF and inflammation markers hs-CRP, and Cys-C levels were assessed by ELISA and immunoturbidimetry. The correlations between serum UA level and VEGF/hs-CRP/Cys-C were analyzed by Pearson tests, diagnostic values of VEGF/hs-CRP/Cys-C were analyzed by receiver operating characteristic curves, and the independent risk factors in HUDR were analyzed by logistic multivariate regression. Serum VEGF/hs-CRP/Cys-C level differences among the T2DM/DR/HUDR groups were statistically significant, with the levels in HUDR > DR > T2DM. Serum UA level in HUDR patients was positively correlated with serum VEGF/hs-CRP/Cys-C. Serum VEGF/hs-CRP/Cys-C assisted in HUDR diagnosis, with their combination showing the greatest diagnostic value. UA/FPG/HbA1C/VEGF/hs-CRP/Cys-C were independent risk factors for HUDR. The incidence of proliferative DR was increased in HUDR patients. Collectively, serum VEGF, hs-CRP, and Cys-C levels in HUDR patients were increased, and HUA might promote DR progression.https://doi.org/10.1515/med-2023-0857type 2 diabetes mellitusretinopathyhyperuricemiavascular endothelial growth factorinflammationhigh-sensitivity c-reactive proteincystatin cpearson testreceiver operating characteristic curvelogistic multiple factor regression analysis |
| spellingShingle | Wei Jing Zhang Jincheng Shi Yanan Zhang Huiqin Wu Yan Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia Open Medicine type 2 diabetes mellitus retinopathy hyperuricemia vascular endothelial growth factor inflammation high-sensitivity c-reactive protein cystatin c pearson test receiver operating characteristic curve logistic multiple factor regression analysis |
| title | Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| title_full | Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| title_fullStr | Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| title_full_unstemmed | Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| title_short | Serum VEGF, high-sensitivity CRP, and cystatin-C assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| title_sort | serum vegf high sensitivity crp and cystatin c assist in the diagnosis of type 2 diabetic retinopathy complicated with hyperuricemia |
| topic | type 2 diabetes mellitus retinopathy hyperuricemia vascular endothelial growth factor inflammation high-sensitivity c-reactive protein cystatin c pearson test receiver operating characteristic curve logistic multiple factor regression analysis |
| url | https://doi.org/10.1515/med-2023-0857 |
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