Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis
Tuberculosis of the central nervous system (CNS-TB) is a critical disease with poor prognosis if not diagnosed and treated early. A regimen of drugs with good CNS penetration is required for treatment. Treatment options are limited in case of hypersensitivity reaction of the recommended regimen. We...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2018-11-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2018.1545516 |
| _version_ | 1797970030648885248 |
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| author | Moni Roy Sharjeel Ahmad Ashish Kumar Roy |
| author_facet | Moni Roy Sharjeel Ahmad Ashish Kumar Roy |
| author_sort | Moni Roy |
| collection | DOAJ |
| description | Tuberculosis of the central nervous system (CNS-TB) is a critical disease with poor prognosis if not diagnosed and treated early. A regimen of drugs with good CNS penetration is required for treatment. Treatment options are limited in case of hypersensitivity reaction of the recommended regimen. We are reporting a rare instance where a patient developed hypersensitivity to both first line agents (isoniazid and rifampin) for CNS-TB and was successfully desensitized against both these medications to complete the treatment course using the rapid desensitization process. There have been reported cases of desensitization to anti tuberculous medications in cases with pulmonary tuberculosis and hypersensitivity reaction. In this review article we discuss the prior used methods of slow and rapid desensitization in case on non-CNS tuberculosis infections. This is the first reported case to use similar method of rapid desensitization in treatment of central nervous system infection. |
| first_indexed | 2024-04-11T03:11:41Z |
| format | Article |
| id | doaj.art-635613db71764ee592e97ed3ba8df989 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:11:41Z |
| publishDate | 2018-11-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-635613db71764ee592e97ed3ba8df9892023-01-02T11:33:11ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662018-11-018634534810.1080/20009666.2018.15455161545516Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosisMoni Roy0Sharjeel Ahmad1Ashish Kumar Roy2OSF Saint Francis Medical CenterUniversity of Illinois College of MedicineOSF Saint Francis Medical CenterTuberculosis of the central nervous system (CNS-TB) is a critical disease with poor prognosis if not diagnosed and treated early. A regimen of drugs with good CNS penetration is required for treatment. Treatment options are limited in case of hypersensitivity reaction of the recommended regimen. We are reporting a rare instance where a patient developed hypersensitivity to both first line agents (isoniazid and rifampin) for CNS-TB and was successfully desensitized against both these medications to complete the treatment course using the rapid desensitization process. There have been reported cases of desensitization to anti tuberculous medications in cases with pulmonary tuberculosis and hypersensitivity reaction. In this review article we discuss the prior used methods of slow and rapid desensitization in case on non-CNS tuberculosis infections. This is the first reported case to use similar method of rapid desensitization in treatment of central nervous system infection.http://dx.doi.org/10.1080/20009666.2018.1545516HypersensitivityCNS infectionCNS tuberculosisrapid desensitizationslow desensitization |
| spellingShingle | Moni Roy Sharjeel Ahmad Ashish Kumar Roy Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis Journal of Community Hospital Internal Medicine Perspectives Hypersensitivity CNS infection CNS tuberculosis rapid desensitization slow desensitization |
| title | Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| title_full | Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| title_fullStr | Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| title_full_unstemmed | Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| title_short | Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| title_sort | successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis |
| topic | Hypersensitivity CNS infection CNS tuberculosis rapid desensitization slow desensitization |
| url | http://dx.doi.org/10.1080/20009666.2018.1545516 |
| work_keys_str_mv | AT moniroy successfulrapidoraldesensitizationfordualhypersensitivitytoisoniazidandrifampinwhiletreatingcentralnervoussystemtuberculosis AT sharjeelahmad successfulrapidoraldesensitizationfordualhypersensitivitytoisoniazidandrifampinwhiletreatingcentralnervoussystemtuberculosis AT ashishkumarroy successfulrapidoraldesensitizationfordualhypersensitivitytoisoniazidandrifampinwhiletreatingcentralnervoussystemtuberculosis |