Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model
Abstract Background Omega-3 fatty acids’ inclusion as feed supplement in the diets of both human and animals has been found to play a significant role in body metabolism. The aim of this present study was to evaluate the effects of graded doses of omega-3 fatty acids on haematology and body weight o...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-04-01
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| Series: | Journal of Basic and Applied Zoology |
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| Online Access: | http://link.springer.com/article/10.1186/s41936-020-00155-1 |
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| author | Emmanuel I. Nnamonu Bernard O. Mgbenka Bede I. Ezewudo Edmund C. Mbegbu Chiemekam S. Ezechukwu Godwin C. Ugwu |
| author_facet | Emmanuel I. Nnamonu Bernard O. Mgbenka Bede I. Ezewudo Edmund C. Mbegbu Chiemekam S. Ezechukwu Godwin C. Ugwu |
| author_sort | Emmanuel I. Nnamonu |
| collection | DOAJ |
| description | Abstract Background Omega-3 fatty acids’ inclusion as feed supplement in the diets of both human and animals has been found to play a significant role in body metabolism. The aim of this present study was to evaluate the effects of graded doses of omega-3 fatty acids on haematology and body weight of adult male and female Rattus norvegicus (Wistar albino rats) as a model animal. Methods A total of seventy-two adult male and female albino rats were randomly assigned into two experimental units. Each unit was grouped into three and received different treatment diets. Blood erythrocytes and weight were sampled on days 0, 14 and 28 to evaluate haematological parameters and body weight. Results Results showed concentration- and time-dependent significant increases (p < 0.05) in the packed cell volume (PCV), haemoglobin (Hb), white blood cells (WBCs), mean cell volume (MCV) and mean cell haemoglobin (MCH) and non-significant change (p > 0.05) in the red blood cells (RBCs) and mean cell haemoglobin concentration (MCHC) in male rats after day 0. In female rats, significant increases (p < 0.05) were recorded in the PCV, Hb, MCV and MCH, whereas no significant increase was observed in the RBCs. Activities of WBCs and MCHC showed mixed trend in female rats. The results of the body weight recorded non-significant increases (p > 0.05) in both experimental units. Conclusion Our findings depict that the use of omega-3 fatty acids in the diets of both male and female rats produced a dose-dependent effect on blood formation while its role in controlling weight gain was observed. Hence, its intake in both animal and human diets should be rightly prescribed. |
| first_indexed | 2024-12-13T06:59:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2090-990X |
| language | English |
| last_indexed | 2024-12-13T06:59:03Z |
| publishDate | 2020-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Basic and Applied Zoology |
| spelling | doaj.art-63583ee0c5fc4296b27dbef49beabd1e2022-12-21T23:55:59ZengSpringerOpenJournal of Basic and Applied Zoology2090-990X2020-04-018111810.1186/s41936-020-00155-1Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus modelEmmanuel I. Nnamonu0Bernard O. Mgbenka1Bede I. Ezewudo2Edmund C. Mbegbu3Chiemekam S. Ezechukwu4Godwin C. Ugwu5Federal College of Education, School of Sciences, Department of Biology, School of SciencesFaculty of Biological Sciences, Department of Zoology and Environmental Biology, University of NigeriaFaculty of Biological Sciences, Department of Zoology and Environmental Biology, University of NigeriaFaculty of Veterinary Medicine, Department of Veterinary Physiology and Pharmacology, University of NigeriaFaculty of Biological Sciences, Department of Zoology and Environmental Biology, University of NigeriaFaculty of Biological Sciences, Department of Zoology and Environmental Biology, University of NigeriaAbstract Background Omega-3 fatty acids’ inclusion as feed supplement in the diets of both human and animals has been found to play a significant role in body metabolism. The aim of this present study was to evaluate the effects of graded doses of omega-3 fatty acids on haematology and body weight of adult male and female Rattus norvegicus (Wistar albino rats) as a model animal. Methods A total of seventy-two adult male and female albino rats were randomly assigned into two experimental units. Each unit was grouped into three and received different treatment diets. Blood erythrocytes and weight were sampled on days 0, 14 and 28 to evaluate haematological parameters and body weight. Results Results showed concentration- and time-dependent significant increases (p < 0.05) in the packed cell volume (PCV), haemoglobin (Hb), white blood cells (WBCs), mean cell volume (MCV) and mean cell haemoglobin (MCH) and non-significant change (p > 0.05) in the red blood cells (RBCs) and mean cell haemoglobin concentration (MCHC) in male rats after day 0. In female rats, significant increases (p < 0.05) were recorded in the PCV, Hb, MCV and MCH, whereas no significant increase was observed in the RBCs. Activities of WBCs and MCHC showed mixed trend in female rats. The results of the body weight recorded non-significant increases (p > 0.05) in both experimental units. Conclusion Our findings depict that the use of omega-3 fatty acids in the diets of both male and female rats produced a dose-dependent effect on blood formation while its role in controlling weight gain was observed. Hence, its intake in both animal and human diets should be rightly prescribed.http://link.springer.com/article/10.1186/s41936-020-00155-1Feed supplementBody weightHaematological parametersOmega-3 fatty acidsRats |
| spellingShingle | Emmanuel I. Nnamonu Bernard O. Mgbenka Bede I. Ezewudo Edmund C. Mbegbu Chiemekam S. Ezechukwu Godwin C. Ugwu Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model Journal of Basic and Applied Zoology Feed supplement Body weight Haematological parameters Omega-3 fatty acids Rats |
| title | Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model |
| title_full | Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model |
| title_fullStr | Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model |
| title_full_unstemmed | Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model |
| title_short | Omega-3 fatty acids as feed supplement modulates blood formation and body weight in Rattus norvegicus model |
| title_sort | omega 3 fatty acids as feed supplement modulates blood formation and body weight in rattus norvegicus model |
| topic | Feed supplement Body weight Haematological parameters Omega-3 fatty acids Rats |
| url | http://link.springer.com/article/10.1186/s41936-020-00155-1 |
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