Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement
<i>Background</i>: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. <i>Objective</i>: To identify differences in clinical and post-surgical follow-up between patients with focal mening...
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| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/10/752 |
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| author | Luca De Palma Chiara Pepi Alessandro De Benedictis Nicola Pietrafusa Angela Mastronuzzi Antonella Cacchione Giusy Carfì-Pavia Camilla Rossi-Espagnet Francesca Diomedi-Camassei Sabrina Rossi Antonio Napolitano Andrea Carai Giovanna Stefania Colafati Daniela Longo Paolo Curatolo Federico Vigevano Carlo Efisio Marras Nicola Specchio |
| author_facet | Luca De Palma Chiara Pepi Alessandro De Benedictis Nicola Pietrafusa Angela Mastronuzzi Antonella Cacchione Giusy Carfì-Pavia Camilla Rossi-Espagnet Francesca Diomedi-Camassei Sabrina Rossi Antonio Napolitano Andrea Carai Giovanna Stefania Colafati Daniela Longo Paolo Curatolo Federico Vigevano Carlo Efisio Marras Nicola Specchio |
| author_sort | Luca De Palma |
| collection | DOAJ |
| description | <i>Background</i>: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. <i>Objective</i>: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. <i>Methods</i>: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. <i>Results</i>: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. <i>Conclusions</i>: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs. |
| first_indexed | 2024-03-10T15:31:32Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T15:31:32Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-635c53dfbd714ec69ff8473af9fba06c2023-11-20T17:35:08ZengMDPI AGBrain Sciences2076-34252020-10-01101075210.3390/brainsci10100752Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal InvolvementLuca De Palma0Chiara Pepi1Alessandro De Benedictis2Nicola Pietrafusa3Angela Mastronuzzi4Antonella Cacchione5Giusy Carfì-Pavia6Camilla Rossi-Espagnet7Francesca Diomedi-Camassei8Sabrina Rossi9Antonio Napolitano10Andrea Carai11Giovanna Stefania Colafati12Daniela Longo13Paolo Curatolo14Federico Vigevano15Carlo Efisio Marras16Nicola Specchio17Rare and Complex Epilepsies, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, ItalyRare and Complex Epilepsies, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, ItalyNeurosurgery Unit, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyRare and Complex Epilepsies, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, ItalyNeuro-Oncology Unit, Department of Onco-Hematology, Cell and Gene Therapy, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuro-Oncology Unit, Department of Onco-Hematology, Cell and Gene Therapy, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyRare and Complex Epilepsies, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyPathology Unit—Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyPathology Unit—Department of Laboratories, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyMedical Physics Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeurosurgery Unit, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyNeuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyChild Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University, 00133 Rome, ItalyDepartment of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, ItalyNeurosurgery Unit, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyRare and Complex Epilepsies, Department of Neurological Science, Bambino Gesù Children’s Hospital, IRCCS, Member of European Reference Network EpiCARE, 00165 Rome, Italy<i>Background</i>: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. <i>Objective</i>: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. <i>Methods</i>: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y. We subsequently stratified patients according to presence of neuroradiological MI. <i>Results</i>: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug- and seizure-free. <i>Conclusions</i>: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.https://www.mdpi.com/2076-3425/10/10/752drug resistant epilepsyepilepsytemporal lobemeningeal neoplasmsneuroepithelial tumorspediatrics |
| spellingShingle | Luca De Palma Chiara Pepi Alessandro De Benedictis Nicola Pietrafusa Angela Mastronuzzi Antonella Cacchione Giusy Carfì-Pavia Camilla Rossi-Espagnet Francesca Diomedi-Camassei Sabrina Rossi Antonio Napolitano Andrea Carai Giovanna Stefania Colafati Daniela Longo Paolo Curatolo Federico Vigevano Carlo Efisio Marras Nicola Specchio Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement Brain Sciences drug resistant epilepsy epilepsy temporal lobe meningeal neoplasms neuroepithelial tumors pediatrics |
| title | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
| title_full | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
| title_fullStr | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
| title_full_unstemmed | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
| title_short | Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement |
| title_sort | early onset epilepsy caused by low grade epilepsy associated tumors and focal meningeal involvement |
| topic | drug resistant epilepsy epilepsy temporal lobe meningeal neoplasms neuroepithelial tumors pediatrics |
| url | https://www.mdpi.com/2076-3425/10/10/752 |
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